{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:57:02Z","timestamp":1790715422327,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Aging","award":["R01AG031253"],"award-info":[{"award-number":["R01AG031253"]}]},{"name":"National Institutes of Aging","award":["R01AG040230"],"award-info":[{"award-number":["R01AG040230"]}]},{"name":"National Institutes of Aging","award":["R21AG041935"],"award-info":[{"award-number":["R21AG041935"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p><jats:bold>A recent study reported lower anxiety in the <jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content> transgenic mouse model of Alzheimer's disease, as measured by reduced time on the open arms of an elevated plus maze. This is important because all behaviors in experimental animals must be interpreted in light of basal anxiety and response to novel environments. We conducted a comprehensive anxiety battery in the <jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content> transgenics and replicated the plus\u2010maze phenotype. However, we found that it did not reflect reduced anxiety, but rather abnormal avoidance of the closed arms on the part of transgenics and within\u2010session habituation to the closed arms on the part of wild\u2010type controls. We noticed that the <jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content> transgenics did not engage in the whisker\u2010barbering behavior typical of mice of this background strain. This is suggestive of abnormal social behavior, and we suspected it might be related to their avoidance of the closed arms on the plus maze. Indeed, transgenic mice exhibited excessive home\u2010cage social behavior and impaired social recognition, and did not permit barbering by wild\u2010type mice when pair\u2010housed. When their whiskers were snipped the <jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content> transgenics no longer avoided the closed arms on the plus maze. Examination of parvalbumin (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) staining showed a 28.9% reduction in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>+ inhibitory interneurons in the barrel fields of <jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content> mice, and loss of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>+ fibers in layers <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and V. This loss of vibrissal inhibition suggests a putatively aversive overstimulation that may be responsible for the transgenics' avoidance of the closed arms in the plus maze<\/jats:bold>.<\/jats:p>","DOI":"10.1111\/gbb.12133","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T14:12:34Z","timestamp":1395411154000},"page":"488-500","source":"Crossref","is-referenced-by-count":99,"title":["Abnormal vibrissa\u2010related behavior and loss of barrel field inhibitory neurons in <scp>5xFAD<\/scp> transgenics"],"prefix":"10.1111","volume":"13","author":[{"given":"T. J.","family":"Flanigan","sequence":"first","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kishan Rao","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dhanushkodi","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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