{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:49:00Z","timestamp":1768549740054,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ontario Mental Health Foundation"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP-84323"],"award-info":[{"award-number":["MOP-84323"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Tourette Syndrome Association of America"},{"name":"N.I.H.","award":["MS40024-01"],"award-info":[{"award-number":["MS40024-01"]}]},{"name":"The Tourette Syndrome Foundation of Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Linkage and association of Tourette Syndrome (TS) and Attention\u2010Deficit\/Hyperactivity Disorder (ADHD) have previously been reported in the 11q24 chromosomal region. To identify the risk gene within the region we studied the potassium inwardly\u2010rectifying channel J5 (<jats:italic>KCNJ5<\/jats:italic>) gene in a sample of 170 nuclear families with TS. We genotyped eight markers across the gene and observed biased transmission of haplotypes from parents to probands in this sample. We then tested these markers in an independent sample of 242 nuclear families with ADHD and found the same haplotype was significantly over transmitted to ADHD probands. Screening of the coding region of <jats:italic>KCNJ5<\/jats:italic> in 48 probands with TS did not identify any variation that could explain the association of the haplotype. We also genotyped two microsatellite markers, one in the promoter and the other in the 3\u2032 region and found no evidence for association for either marker for TS, however, we found significant evidence for association with the 3\u2032 repeat and ADHD. A small gene (<jats:italic>c11orf45<\/jats:italic>) of unknown function lies within the first intron of <jats:italic>KCNJ5<\/jats:italic> that is transcribed in the opposite orientation and this gene may regulate the expression of <jats:italic>KCNJ5<\/jats:italic>. We studied the correlation of the expression of <jats:italic>KCNJ5<\/jats:italic> and the antisense transcript in brain tissues from control individuals and found that the antisense transcript and the short <jats:italic>KCNJ5<\/jats:italic> isoform are co\u2010expressed in three brain regions. The results of this study indicate that <jats:italic>KCNJ5<\/jats:italic> is associated with TS and ADHD in our samples, however, the functional variant(s) remain to be identified.<\/jats:p>","DOI":"10.1111\/gbb.12141","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T14:14:41Z","timestamp":1400508881000},"page":"535-542","source":"Crossref","is-referenced-by-count":12,"title":["Association of the <i><scp>KCNJ5<\/scp><\/i> gene with Tourette Syndrome and Attention\u2010Deficit\/Hyperactivity Disorder"],"prefix":"10.1111","volume":"13","author":[{"given":"L.","family":"Gomez","sequence":"first","affiliation":[{"name":"Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Wigg","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sandor","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Malone","sequence":"additional","affiliation":[{"name":"Holland Bloorview Kids Rehabilitation Hospital  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Barr","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute University Health Network  Toronto Canada"},{"name":"Program in Neurosciences and Mental Health The Hospital for Sick Children  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng786"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. (2013) American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders: DSM\u20105.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/426154"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1669"},{"key":"e_1_2_5_6_1","first-page":"379","volume-title":"Handbook of Tourette's Syndrome and Related Tic and Behavioral Disorders","author":"Barr C.L.","year":"2005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2005.04.006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/302577"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10524"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.016"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.10252"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.19.13176"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.4.12.2622"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/362031a0"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1177\/070674370605100508","article-title":"The Parent Interview for Child Symptoms (PICS): a situation\u2010specific clinical\u2010research interview for attention deficit hyperactivity and related disorders","volume":"50","author":"Ickowicz A.","year":"2006","journal-title":"Can J Psychiatry"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112009"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0160-9327(97)01005-3"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/362127a0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400857"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00015"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05453"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.7.2550-2559.2006"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2834"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2010.10.004"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706729105"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/303093"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.6.1595"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/383251"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/375139"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31195"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00586-X"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.425"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121176998"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1086\/302002"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1192"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.10.004"},{"key":"e_1_2_5_40_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2011.01.007","volume-title":"The genetics of Tourette disorder","author":"State M.W.","year":"2011"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000251211.36868.fe"},{"key":"e_1_2_5_42_1","unstructured":"Tannock R. 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Humphries T.&Schachar R.(2002)Teacher Telephone Interview for Children's Academic Performance Attention Behavior and Learning: DSM\u2010IV Version (TTI\u2010IV).Unpublished Document The Hospital for Sick Children Toronto Canada."},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1086\/302613"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170097"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgbb.12141","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/gbb.12141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:50:41Z","timestamp":1696330241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,19]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/gbb.12141"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12141","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,19]]}}}