{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:11:24Z","timestamp":1764259884732,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R21 DA027001","R21 DA024226"],"award-info":[{"award-number":["R21 DA027001","R21 DA024226"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Individuals with reduced attention and memory cognitive control\u2010related processes may be motivated to smoke as a result of the cognitive enhancing effects of nicotine. Further, nicotine deprivation\u2010induced reductions in cognitive control may negatively reinforce smoking. Minor allele carriers at rs16969968 in the nicotinic acetylcholine receptor \u03b15 subunit gene (CHRNA5<\/jats:styled-content><\/jats:italic>) have been shown to exhibit both reduced cognitive control and greater nicotine dependence. It is therefore of interest to see if variants in this gene moderate the influence of nicotine deprivation on cognitive control. P3b and P3a components of the event\u2010related brain potential waveform evoked by a three\u2010stimulus visual oddball task are widely viewed as positive indices of cognitive control\u2010related processes. We tested the hypothesis that individuals possessing at least one minor allele at rs16969968 in CHRNA5<\/jats:styled-content><\/jats:italic> would show greater nicotine deprivation\u2010induced reductions in P3b and P3a amplitude. The sample included 72 non\u2010Hispanic, Caucasian heavy smokers (54 men and 18 women) with a mean age of 36.11 years (SD<\/jats:styled-content> = 11.57). Participants completed the visual oddball task during counterbalanced nicotine and placebo smoking sessions. Findings indicated that rs16969968 status did not moderate nicotine effects on P3b or P3a, whereas variation in other CHRNA5<\/jats:styled-content><\/jats:italic> polymorphisms, which are not as well characterized and are not in linkage disequilibrium with rs16969968, predicted nicotine deprivation\u2010induced reduction of P3a amplitude: rs588765 (F<\/jats:italic>1,68<\/jats:sub> = 7.74, P<\/jats:italic> = 0.007) and rs17408276 (F<\/jats:italic>1,67<\/jats:sub> = 7.34, P<\/jats:italic> = 0.009). Findings are interpreted in the context of vulnerability alleles that may predict nicotine effects on cognitive control.<\/jats:p>","DOI":"10.1111\/gbb.12151","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T13:24:10Z","timestamp":1403011450000},"page":"626-632","source":"Crossref","is-referenced-by-count":8,"title":["CHRNA5<\/scp> variants moderate the effect of nicotine deprivation on a neural index of cognitive control"],"prefix":"10.1111","volume":"13","author":[{"given":"D. E.","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Health Outcomes and Behavior H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA"},{"name":"Department of Oncologic Sciences University of South Florida Tampa FL USA"},{"name":"Department of Psychology University of South Florida Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"MacQueen","sequence":"additional","affiliation":[{"name":"Department of Psychology University of South Florida Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. G.","family":"Jentink","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Y.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oncologic Sciences University of South Florida Tampa FL USA"},{"name":"Department of Cancer Prevention and Control H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Oncologic Sciences University of South Florida Tampa FL USA"},{"name":"Department of Biostatistics H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Drobes","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA"},{"name":"Department of Oncologic Sciences University of South Florida Tampa FL USA"},{"name":"Department of Psychology University of South Florida Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2009.00885.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2008.00130.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.159"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.08.003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1848-1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721410370295"},{"volume-title":"Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine use and Dependence","year":"2009","author":"Lerman C.","key":"e_1_2_5_9_1"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026043451401"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.12.017"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.04.019"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.12.012"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2010.21528"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001053"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.42"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.7.4.354"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31126"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgbb.12151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgbb.12151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T10:55:20Z","timestamp":1694343320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,23]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/gbb.12151"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12151","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"type":"print","value":"1601-1848"},{"type":"electronic","value":"1601-183X"}],"subject":[],"published":{"date-parts":[[2014,7,23]]}}}