{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:41:59Z","timestamp":1790836919508,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5IO1RX000458"],"award-info":[{"award-number":["5IO1RX000458"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Maternal care is an indispensable component of offspring survival and development in all mammals and necessary for reproductive success. Although brain areas regulating maternal behaviors are innervated by serotonergic afferents, very little is known about the role of this neurotransmitter in these behaviors. To evaluate the contribution of serotonin to maternal care, we used mice with a null mutation in the gene for tryptophan hydroxylase\u20102 (TPH2), which results in a genetic depletion of brain serotonin, and tested them in a wide range of maternal behavior paradigms. We found that litters born to and reared by TPH2<jats:sup>\u2212\/\u2212<\/jats:sup> mothers showed decreased survival, lower weaning weights and increased cannibalization. In addition, TPH2<jats:sup>\u2212\/\u2212<\/jats:sup> mothers performed poorly in pup retrieval, huddling, nest construction and high\u2010arched back nursing. Aggression in TPH2<jats:sup>\u2212\/\u2212<\/jats:sup> dams was not triggered by lactation and was steadily high. Survival and weaning weight deficits of TPH2<jats:sup>\u2212\/\u2212<\/jats:sup> pups were rescued by cross\u2010fostering and in litters of mixed genotype (TPH2<jats:sup>\u2212\/\u2212<\/jats:sup> and TPH2<jats:sup>\u2212\/+<\/jats:sup>). However, the maternal behaviors of TPH2<jats:sup>\u2212\/\u2212<\/jats:sup> dams did not improve when rearing either TPH2<jats:sup>+\/+<\/jats:sup> pups or mixed\u2010genotype litters. In addition, TPH2<jats:sup>\u2212\/\u2212<\/jats:sup> pups significantly worsened the behavior of TPH2<jats:sup>+\/+<\/jats:sup> dams with respect to cannibalism, weaning weight and latency to attack. Olfactory and auditory functions of TPH2<jats:sup>\u2212\/\u2212<\/jats:sup> females or anxiety\u2010like behaviors did not account for these maternal alterations as they were equal to their TPH2<jats:sup>+\/+<\/jats:sup> counterparts. These findings illustrate a profound influence of brain serotonin on virtually all elements of maternal behavior and establish that TPH2<jats:sup>\u2212\/\u2212<\/jats:sup> pups can engender maladaptive mothering in dams of both genotypes.<\/jats:p>","DOI":"10.1111\/gbb.12159","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T04:59:00Z","timestamp":1406782740000},"page":"579-591","source":"Crossref","is-referenced-by-count":61,"title":["Brain serotonin determines maternal behavior and offspring survival"],"prefix":"10.1111","volume":"13","author":[{"given":"M.","family":"Angoa\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Research &amp; Development Service, John D. Dingell VA Medical Center  Detroit MI USA"},{"name":"Department of Psychiatry &amp; Behavioral Neurosciences  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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W.","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology &amp; Head Neck Surgery Wayne State University School of Medicine  Detroit MI USA"},{"name":"Department of Communication Sciences &amp; Disorders Wayne State University College of Liberal Arts &amp; Sciences  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Research &amp; Development Service, John D. 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