{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:59:33Z","timestamp":1791388773816,"version":"4.3.3"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HD057853"],"award-info":[{"award-number":["P01HD057853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>\n                    Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain\u2010containing protein 2 (\n                    <jats:italic>DCDC2<\/jats:italic>\n                    ) have been associated with dyslexia, impairments in phonological processing and in short\u2010term\/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the\n                    <jats:italic>Dcdc2<\/jats:italic>\n                    gene in mice. Several behavioral tasks, including a modified pre\u2010pulse inhibition paradigm (to examine auditory processing), a 4\/8 radial arm maze (to assess\/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of\n                    <jats:italic>Dcdc2<\/jats:italic>\n                    mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in\n                    <jats:italic>\n                      Dcdc2\n                      <jats:sup>del2\/del2<\/jats:sup>\n                    <\/jats:italic>\n                    mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of\n                    <jats:italic>DCDC2<\/jats:italic>\n                    with specific impairments of phonological processing and memory ability.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12170","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T08:59:02Z","timestamp":1407747542000},"page":"802-811","source":"Crossref","is-referenced-by-count":49,"title":["Mutation of\n                    <i>Dcdc2<\/i>\n                    in mice leads to impairments in auditory processing and memory ability"],"prefix":"10.1111","volume":"13","author":[{"given":"D. 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