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Genetically modified mice with low levels of <jats:styled-content style=\"fixed-case\">NR1<\/jats:styled-content> subunit (<jats:styled-content style=\"fixed-case\">NR1<\/jats:styled-content> knockdown mice) have reduced receptor levels throughout development, and have robust abnormalities in behaviours that are relevant to schizophrenia. We traced the onset and severity of these behaviours at three developmental stages to understand when in development the underlying circuits depend on intact <jats:styled-content style=\"fixed-case\">NMDAR<\/jats:styled-content> function. We examined social behaviour, working memory, executive function, locomotor activity and stereotypy at 3, 6 and 12\u2009weeks of age in <jats:styled-content style=\"fixed-case\">NR1<\/jats:styled-content> knockdown mice and their wild\u2010type littermates. We discovered that each of these behaviours had a unique developmental trajectory in mutant mice, and males showed an earlier onset and severity than females in several behaviours. Hyperlocomotion was most substantial in juvenile mice and plateaued in adult mice, whereas stereotypy progressively worsened with age. Impairments in working memory and sociability were sexually dimorphic, with deficits first detected in peri\u2010adolescent males but only detected in adult females. Interestingly, executive function was most impaired in peri\u2010adolescent mice of either sex. Furthermore, while juvenile mutant mice had some ability to problem solve in the puzzle box test, the same mice lost this ability when tested 4\u2009weeks later. Our studies highlight key developmental periods for males and females in the expression of behaviours that are relevant to psychiatric disorders.<\/jats:p>","DOI":"10.1111\/gbb.12183","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T06:34:51Z","timestamp":1413786891000},"page":"850-862","source":"Crossref","is-referenced-by-count":47,"title":["<scp>NMDA<\/scp> receptor\u2010deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities"],"prefix":"10.1111","volume":"13","author":[{"given":"M.","family":"Milenkovic","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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