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Mutations in <jats:italic>Phosphatase and tensin homolog<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content><\/jats:italic>), one of several <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> risk factors encoding negative regulators of the <jats:styled-content style=\"fixed-case\">PI3K<\/jats:styled-content>\u2013Akt\u2013<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> pathway, have been reported in individuals with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and comorbid macrocephaly. We previously showed that a mouse model of <jats:italic>Pten<\/jats:italic> germline haploinsufficiency (<jats:italic>Pten<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>) has selective deficits, primarily in social behavior, along with broad overgrowth of the brain. Here, we further examine the social behavior of <jats:italic>Pten<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> male mice in the resident\u2013intruder test of aggression, using a comprehensive behavioral analysis to obtain an overall picture of the agonistic, non\u2010agonistic and non\u2010social behavior patterns of <jats:italic>Pten<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice during a free interaction with a novel conspecific. <jats:italic>Pten<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> male mice were involved in less aggression than their wild\u2010type littermates. <jats:italic>Pten<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice also performed less social investigation, including anogenital investigation and approaching and\/or attending to the intruder, which is consistent with our previous finding of decreased sociability in the social approach test. In contrast to these decreases in social behaviors, <jats:italic>Pten<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice showed increased digging. In summary, we report decreased aggression and increased repetitive behavior in <jats:italic>Pten<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice, thus extending our characterization of this model of an <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> risk factor that features brain overgrowth and social deficits.<\/jats:p>","DOI":"10.1111\/gbb.12192","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T05:19:36Z","timestamp":1420521576000},"page":"145-157","source":"Crossref","is-referenced-by-count":43,"title":["Decreased aggression and increased repetitive behavior in <i>Pten<\/i> haploinsufficient mice"],"prefix":"10.1111","volume":"14","author":[{"given":"A. 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