{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:26:51Z","timestamp":1792798011122,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty of Medicine of McGill University","id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Norlien Foundation"},{"name":"WOCO Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We examined transgenerational effects of maternal childhood adversity on child temperament and a functional promoter polymorphism, 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                    , in the serotonin\u2010transporter gene (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">SLC6A4<\/jats:styled-content>\n                    <\/jats:italic>\n                    ) as potential moderators of such maternal influences in 154 mother\u2013child dyads, recruited into a longitudinal birth cohort study. We examined the interactive effects of maternal childhood experience using an integrated measure derived from Childhood Trauma Questionnaire (\n                    <jats:styled-content style=\"fixed-case\">CTQ<\/jats:styled-content>\n                    ) and Parental Bonding Index (\n                    <jats:styled-content style=\"fixed-case\">PBI<\/jats:styled-content>\n                    ). Triallelic genotyping of 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                    was performed. A measure of \u2018negative emotionality\/behavioural dysregulation\u2019 was derived from the Early Childhood Behaviour Questionnaire at 18 and 36 months. Negative emotionality\/behavioural dysregulation was highly stable between 18 and 36 months and predicted psychosocial problems at 60 months. After controlling multiple demographics as well as both previous and concurrent maternal depression there was a significant interaction effect of maternal childhood adversity and offspring 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content>\n                    genotype on child negative emotionality\/behavioural dysregulation (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    = 1.03,\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>11,115<\/jats:sub>\n                    = 2.71,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .01). The results suggest a transgenerational effect of maternal developmental history on emotional function in the offspring, describing a pathway that likely contributes to the familial transmission of vulnerability for psychopathology.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12205","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T10:34:37Z","timestamp":1424082877000},"page":"229-237","source":"Crossref","is-referenced-by-count":40,"title":["Maternal childhood adversity and child temperament: An association moderated by child 5\u2010\n                    <scp>HTTLPR<\/scp>\n                    genotype"],"prefix":"10.1111","volume":"14","author":[{"given":"Andr\u00e9e\u2010Anne","family":"Bouvette\u2010Turcot","sequence":"first","affiliation":[{"name":"Douglas Mental Health University Institute of McGill University"},{"name":"D\u00e9partement de Psychologie Universit\u00e9 de Montr\u00e9al"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wazana","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute of McGill University"},{"name":"Centre for Child Development and Mental Health Jewish General Hospital of McGill University  Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Sokolowski","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology University of Toronto  Toronto"},{"name":"St. Joseph's Hospital and Department of Psychiatry McMaster University  Hamilton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Gaudreau","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute of McGill University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Neurosciences Offord Center for Child Studies, McMaster University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Deslauriers","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychologie Universit\u00e9 de Montr\u00e9al"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Center for Addiction and Mental Health University of Toronto  Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences McMaster University"},{"name":"Women's Health Concerns Clinic St. Joseph's Healthcare  Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Meaney","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute of McGill University"},{"name":"Singapore Institute for Clinical Sciences  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the MAVAN Research 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