{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:37:48Z","timestamp":1791409068148,"version":"4.3.3"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR926"],"award-info":[{"award-number":["FOR926"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Many studies using genetic mouse models are performed with animals on either one of the two closely related genetic backgrounds, <jats:styled-content style=\"fixed-case\">C57BL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">6J<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">C57BL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">6N<\/jats:styled-content>. These strains differ only in a few genetic loci, but have some phenotypic differences that also affect behavior. In order to determine the effects of chronic stress hormone exposure, which is relevant for the pathogenesis of psychiatric disorders, we investigated here the behavioral manifestations of long\u2010term increase in corticosterone levels. Thus, male mice from both sub\u2010strains were subcutaneously implanted with corticosterone (20 mg) or placebo pellets that released the hormone for a period of 21 days and resulted in significantly elevated plasma corticosterone levels. Corticosterone significantly increased food intake in <jats:styled-content style=\"fixed-case\">B6N<\/jats:styled-content>, but not in <jats:styled-content style=\"fixed-case\">B6J<\/jats:styled-content> mice. At various time points after pellet implantation, we performed tests relevant to activity and emotional behaviors. <jats:styled-content style=\"fixed-case\">B6J<\/jats:styled-content> mice displayed a generally higher activity in the home cage and the open field. Corticosterone decreased the activity. In <jats:styled-content style=\"fixed-case\">B6N<\/jats:styled-content> mice, corticosterone also decreased sucrose preference, worsened the coat state and increased forced swim immobility, while it had no effect in the <jats:styled-content style=\"fixed-case\">B6J<\/jats:styled-content> strain. Altogether, these results indicate that <jats:styled-content style=\"fixed-case\">B6N<\/jats:styled-content> mice are more sensitive to some of the effects of chronic corticosterone treatment than <jats:styled-content style=\"fixed-case\">B6J<\/jats:styled-content> mice.<\/jats:p>","DOI":"10.1111\/gbb.12208","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T07:19:28Z","timestamp":1425626368000},"page":"292-300","source":"Crossref","is-referenced-by-count":69,"title":["Effect of chronic corticosterone application on depression\u2010like behavior in <scp>C57BL<\/scp>\/<scp>6N<\/scp> and <scp>C57BL<\/scp>\/<scp>6J<\/scp> mice"],"prefix":"10.1111","volume":"14","author":[{"given":"M.","family":"Sturm","sequence":"first","affiliation":[{"name":"Institute of Molecular Psychiatry University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute of 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