{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:17:37Z","timestamp":1770527857157,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["UF100463"],"award-info":[{"award-number":["UF100463"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0800523\/8647"],"award-info":[{"award-number":["G0800523\/8647"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["097831\/Z\/11\/Z"],"award-info":[{"award-number":["097831\/Z\/11\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["102215\/2\/13\/2"],"award-info":[{"award-number":["102215\/2\/13\/2"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G1000569\/1"],"award-info":[{"award-number":["G1000569\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J003719\/1"],"award-info":[{"award-number":["MR\/J003719\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["060774 and 076566"],"award-info":[{"award-number":["060774 and 076566"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["090532\/Z\/09\/Z"],"award-info":[{"award-number":["090532\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP 82893"],"award-info":[{"award-number":["MOP 82893"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council of Australia","award":["572613"],"award-info":[{"award-number":["572613"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin\u2010<jats:styled-content style=\"fixed-case\">18B<\/jats:styled-content> gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome\u2010wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths\u2010related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (<jats:styled-content style=\"fixed-case\">ALSPAC<\/jats:styled-content>), (<jats:italic>N<\/jats:italic>\u2009=\u20093819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (<jats:styled-content style=\"fixed-case\">SLIC<\/jats:styled-content>) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin\u2010<jats:styled-content style=\"fixed-case\">18B<\/jats:styled-content> and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin\u2010<jats:styled-content style=\"fixed-case\">18B<\/jats:styled-content> variant is unlikely to be a main factor contributing to mathematical abilities.<\/jats:p>","DOI":"10.1111\/gbb.12213","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T08:20:07Z","timestamp":1426494007000},"page":"369-376","source":"Crossref","is-referenced-by-count":21,"title":["Lack of replication for the myosin\u2010<scp>18B<\/scp> association with mathematical ability in independent cohorts"],"prefix":"10.1111","volume":"14","author":[{"given":"K. A.","family":"Pettigrew","sequence":"first","affiliation":[{"name":"School of Medicine University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. F.","family":"Fajutrao Valles","sequence":"additional","affiliation":[{"name":"School of Medicine University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy Ludwig\u2010Maximilians\u2010University  Munich Germany"},{"name":"Department of Psychology University of York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Northstone","sequence":"additional","affiliation":[{"name":"School of Social and Community Medicine University of Bristol  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ring","sequence":"additional","affiliation":[{"name":"School of Social and Community Medicine University of Bristol  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pennell","sequence":"additional","affiliation":[{"name":"School of Women's and Infants' Health University of Western Australia  Crawley Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Women's and Infants' Health University of Western Australia  Crawley Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Leavett","sequence":"additional","affiliation":[{"name":"Department of Psychology University of York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Hayiou\u2010Thomas","sequence":"additional","affiliation":[{"name":"Department of Psychology University of York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. H.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics Oxford University  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. E.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Psycholinguistics"},{"name":"Donders Institute for Brain, Cognition and Behaviour Radboud University  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The SLI Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. O.","family":"Whitehouse","sequence":"additional","affiliation":[{"name":"St. Johns College University of Oxford  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Snowling","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology"},{"name":"A list of SLIC members can be found in the Acknowledgements"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. F.","family":"Newbury","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics Oxford University  UK"},{"name":"A list of SLIC members can be found in the Acknowledgements"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-1996","authenticated-orcid":false,"given":"S.","family":"Paracchini","sequence":"additional","affiliation":[{"name":"School of Medicine University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/302698"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.116"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096374"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys064"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2012.04.001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231022"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201536"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063859"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5204"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.learninstruc.2013.02.004"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00553.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2006.02.007"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00364.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52891-9.00023-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2009.02114.x"},{"key":"e_1_2_5_17_1","first-page":"767","article-title":"The diagnosis and management of dyscalculia","volume":"109","author":"Kaufmann L.","year":"2012","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2009.02164.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.148"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2014.899570"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103537"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02662.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12091"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes5020285"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91944-H"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135550"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12127"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8279.2011.02033.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-0663.96.3.504"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-011-9091-6"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07121872"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.02.005"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2006.00312.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1086\/338649"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1086\/421529"},{"key":"e_1_2_5_38_1","volume-title":"Wechsler Intelligence Scale for Children\u00a0\u2013\u00a0Third UK Edition","author":"Wechsler D.","year":"1992"},{"key":"e_1_2_5_39_1","volume-title":"Wechsler Adult Intelligence Scale\u00a0\u2013\u00a0Third UK Edition (WAIS\u2010III UK)","author":"Wechsler D.","year":"1997"},{"key":"e_1_2_5_40_1","volume-title":"Wechsler Individual Achievement Test\u00a0\u2013\u00a0Second UK Edition (WIAT\u2010II UK)","author":"Wechsler D.","year":"2005"},{"key":"e_1_2_5_41_1","unstructured":"Western Australian Government Department of Education and Training(2012) Western Australian Literacy and Numeracy Assessment."},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1086\/512821"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgbb.12213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/gbb.12213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:47:23Z","timestamp":1696315643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/gbb.12213"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12213","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}