{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T15:12:39Z","timestamp":1721661159303},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH grants","award":["MH064489","MH093320","MH106978"],"award-info":[{"award-number":["MH064489","MH093320","MH106978"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Monoamine uptake inhibitors are common treatments for depression; however, the therapeutic efficacy of these drugs varies widely. Two factors that are commonly linked to clinical outcome are age and serotonin transporter (<jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content>) genotype. Mouse models provide powerful tools to study consequences of age and genotype on antidepressant\u2010like efficacy; however, to date, systematic studies of this nature are lacking. Here, we used the tail suspension test (<jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>), a preclinical assay for antidepressant efficacy, to gain insight into age and <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content> genotype dependency of immobility time in the <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> under control conditions (saline injection) and in response to the tricyclic antidepressant, desipramine (<jats:styled-content style=\"fixed-case\">DMI<\/jats:styled-content>). Immobility after saline injection in juvenile, adolescent, adult, mature adult and middle\u2010aged mice (postnatal days 21, 28, 90, 210 and 300, respectively) significantly increased with age; however, the rate of increase was slower for <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content> null (\u2212\/\u2212) mice than for wild\u2010type (+\/+) or heterozygote (+\/\u2212) mice. Desipramine reduced immobility across ages and <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content> genotypes. Middle\u2010aged, but not adult, <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>\u2212\/\u2212<\/jats:sup> mice were significantly more sensitive to DMI than age\u2010matched <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>+\/+<\/jats:sup> or <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>+\/\u2212<\/jats:sup> mice. Desipramine was less potent in middle\u2010aged <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>+\/+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>+\/\u2212<\/jats:sup> mice than in adult <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>+\/+<\/jats:sup> or <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>+\/\u2212<\/jats:sup> mice. Regardless of age, <jats:styled-content style=\"fixed-case\">DMI<\/jats:styled-content>'s maximal effects were greater in <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>\u2212\/\u2212<\/jats:sup> mice than in <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>+\/+<\/jats:sup> or <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content><jats:sup>+\/\u2212<\/jats:sup> mice. These results show that immobility time in the <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> varies as a function of age and <jats:styled-content style=\"fixed-case\">SERT<\/jats:styled-content> genotype, underscoring the utility of the <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> as a potential model to examine age\u2010 and SERT genotype\u2010dependent influences on antidepressant response.<\/jats:p>","DOI":"10.1111\/gbb.12238","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T17:41:47Z","timestamp":1438882907000},"page":"543-549","source":"Crossref","is-referenced-by-count":8,"title":["Antidepressant\u2010like effects and basal immobility depend on age and serotonin transporter genotype"],"prefix":"10.1111","volume":"14","author":[{"given":"N. 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