{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:25:26Z","timestamp":1789928726655,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA018799"],"award-info":[{"award-number":["AA018799"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p><jats:italic>Drosophila<\/jats:italic> groom away debris and pathogens from the body using their legs in a stereotyped sequence of innate motor behaviors. Here, we investigated one aspect of the grooming repertoire by characterizing the <jats:styled-content style=\"fixed-case\">D1<\/jats:styled-content> family dopamine receptor, <jats:styled-content style=\"fixed-case\">DopR<\/jats:styled-content>. Removal of <jats:italic><jats:styled-content style=\"fixed-case\">DopR<\/jats:styled-content><\/jats:italic> results in decreased hind leg grooming, as substantiated by quantitation of dye remaining on mutant and <jats:styled-content style=\"fixed-case\">RNAi<\/jats:styled-content> animals vs. controls and direct scoring of behavioral events. These data are also supported by pharmacological results that <jats:styled-content style=\"fixed-case\">D1<\/jats:styled-content> receptor agonists fail to potentiate grooming behaviors in headless <jats:italic><jats:styled-content style=\"fixed-case\">DopR<\/jats:styled-content><\/jats:italic> flies. <jats:styled-content style=\"fixed-case\">DopR<\/jats:styled-content> protein is broadly expressed in the neuropil of the thoracic ganglion and overlaps with <jats:styled-content style=\"fixed-case\">TH<\/jats:styled-content>\u2010positive dopaminergic neurons. Broad neuronal expression of dopamine receptor in mutant animals restored normal grooming behaviors. These data provide evidence for the role of <jats:italic><jats:styled-content style=\"fixed-case\">DopR<\/jats:styled-content><\/jats:italic> in potentiating hind leg grooming behaviors in the thoracic ganglion of adult <jats:italic>Drosophila<\/jats:italic>. This is a remarkable juxtaposition to the considerable role of <jats:styled-content style=\"fixed-case\">D1<\/jats:styled-content> family dopamine receptors in rodent grooming, and future investigations of evolutionary relationships of circuitry may be warranted.<\/jats:p>","DOI":"10.1111\/gbb.12264","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T19:45:50Z","timestamp":1452455150000},"page":"327-334","source":"Crossref","is-referenced-by-count":26,"title":["The <scp>D1<\/scp> family dopamine receptor, <i><scp>DopR<\/scp><\/i>, potentiates hind leg grooming behavior in <i>Drosophila<\/i>"],"prefix":"10.1111","volume":"15","author":[{"given":"E.","family":"Pitmon","sequence":"first","affiliation":[{"name":"Department of Biology Williams College  Williamstown MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Biology Williams College  Williamstown MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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