{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T18:58:00Z","timestamp":1777316280807,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Neurofibromatosis type\u20101 (<jats:styled-content style=\"fixed-case\">NF1<\/jats:styled-content>) is a common neurogenetic disorder and an important cause of intellectual disability. Brain\u2010behaviour associations can be examined <jats:italic>in vivo<\/jats:italic> using morphometric magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and diffusion tensor imaging (<jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>) to study brain structure. Here, we studied structural and behavioural phenotypes in heterozygous Nf1 mice (Nf1<jats:sup>+\/\u2212<\/jats:sup>) using <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>\u2010weighted imaging <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>, with a focus on social recognition deficits. We found that Nf1<jats:sup>+\/\u2212<\/jats:sup> mice have larger volumes than wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) mice in regions of interest involved in social cognition, the prefrontal cortex (<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>) and the caudate\u2010putamen (<jats:styled-content style=\"fixed-case\">CPu<\/jats:styled-content>). Higher diffusivity was found across a distributed network of cortical and subcortical brain regions, within and beyond these regions. Significant differences were observed for the social recognition test. Most importantly, significant structure\u2013function correlations were identified concerning social recognition performance and <jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content> volumes in Nf1<jats:sup>+\/\u2212<\/jats:sup> mice. Analyses of spatial learning corroborated the previously known deficits in the mutant mice, as corroborated by platform crossings, training quadrant time and average proximity measures. Moreover, linear discriminant analysis of spatial performance identified 2 separate sub\u2010groups in Nf1<jats:sup>+\/\u2212<\/jats:sup> mice. A significant correlation between quadrant time and <jats:styled-content style=\"fixed-case\">CPu<\/jats:styled-content> volumes was found specifically for the sub\u2010group of Nf1<jats:sup>+\/\u2212<\/jats:sup> mice with lower spatial learning performance, suggesting additional evidence for reorganization of this region. We found strong evidence that social and spatial cognition deficits can be associated with <jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CPu<\/jats:styled-content> structural changes and reorganization in <jats:styled-content style=\"fixed-case\">NF1<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/gbb.12305","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T11:14:32Z","timestamp":1465557272000},"page":"637-646","source":"Crossref","is-referenced-by-count":20,"title":["Brain and behaviour phenotyping of a mouse model of neurofibromatosis type\u20101: an <scp>MRI<\/scp>\/<scp>DTI<\/scp> study on social cognition"],"prefix":"10.1111","volume":"15","author":[{"given":"L. I.","family":"Petrella","sequence":"first","affiliation":[{"name":"Institute of Nuclear Science Applied to Health University of Coimbra  Coimbra Portugal"},{"name":"Center for Neuroscience and Cell Biology\u00a0\u2013\u00a0Institute of Biomedical Imaging and Life Science (CNC.IBILI) University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurobiology University of California  Los Angeles CA USA"},{"name":"Department of Psychology University of California  Los Angeles CA USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California  Los Angeles CA USA"},{"name":"Integrative Center for Learning and Memory University of California  Los Angeles CA USA"},{"name":"Brain Research Institute University of California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"Sereno","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Science Applied to Health University of Coimbra  Coimbra Portugal"},{"name":"Center for Neuroscience and Cell Biology\u00a0\u2013\u00a0Institute of Biomedical Imaging and Life Science (CNC.IBILI) University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. I.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Science Applied to Health University of Coimbra  Coimbra Portugal"},{"name":"Center for Neuroscience and Cell Biology\u00a0\u2013\u00a0Institute of Biomedical Imaging and Life Science (CNC.IBILI) University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Neurobiology University of California  Los Angeles CA USA"},{"name":"Department of Psychology University of California  Los Angeles CA USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California  Los Angeles CA USA"},{"name":"Integrative Center for Learning and Memory University of California  Los Angeles CA USA"},{"name":"Brain Research Institute University of California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Castelo\u2010Branco","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Science Applied to Health University of Coimbra  Coimbra Portugal"},{"name":"Center for Neuroscience and Cell Biology\u00a0\u2013\u00a0Institute of Biomedical Imaging and Life Science (CNC.IBILI) University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.60.110707.163514"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000099080.90726.BA"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)00008-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature711"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.060.Neurofibromin"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380001500303"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000032370.68306.8A"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.12.002"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22161"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9590"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.12.1904"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.26.3009"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047854"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2012.04399.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.09.043"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2014.0334"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-131"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0323-1"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3822"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.4.914"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32280"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2004.05.003"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2013.07.011"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22334"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8225"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)01133-0"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1546"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(99)00024-8"},{"key":"e_1_2_5_31_1","unstructured":"Santos A.(2011). Visual\u2010callosal white matter pathways in neurofibromatosis type 1 : a Diffusion Tensor Imaging\u00a0\u2013\u00a0Fiber Tracking (DTI\u2010FT) study. Fac. Sci. Technol. Univ. Coimbra. 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