{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:27:04Z","timestamp":1778545624167,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 DA027001"],"award-info":[{"award-number":["R21 DA027001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 DA024226"],"award-info":[{"award-number":["R21 DA024226"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Nicotine withdrawal\u2010related disruption of cognitive control may contribute to the reinforcement of tobacco use. Identification of gene variants that predict this withdrawal phenotype may lead to tailored pharmacotherapy for smoking cessation. Variation on the cannabinoid receptor 1 gene (<jats:italic>CNR1<\/jats:italic>) has been related to nicotine dependence, and CNR1 antagonists may increase attention and memory functioning. We targeted <jats:italic>CNR1<\/jats:italic> variants as moderators of a validated neural marker of nicotine withdrawal\u2010related cognitive disruption. <jats:italic>CNR1<\/jats:italic> polymorphisms comprising the \u2018TAG\u2019 haplotype (rs806379, rs1535255 and rs2023239) were tested independently, as no participants in this sample possessed this haplotype. Nicotine withdrawal\u2010related cognitive disruption was indexed as increased resting electroencephalogram (EEG) alpha\u20101 power density across 17 electrodes. Seventy\u2010three Caucasian Non\u2010Hispanic smokers (\u226515 cigarettes per day) visited the laboratory on two occasions following overnight smoking\/nicotine deprivation. Either two nicotine or two placebo cigarettes were smoked prior to collecting EEG data at each session. Analyses showed that rs806379 moderated the effects of nicotine deprivation increasing slow wave EEG (<jats:italic>P<\/jats:italic> = 0.004). Smokers homozygous for the major allele exhibited greater nicotine withdrawal\u2010related cognitive disruption. The current findings suggest potential efficacy of cannabinoid receptor antagonism as a pharmacotherapy approach for smoking cessation among individuals who exhibit greater nicotine withdrawal\u2010related cognitive disruption.<\/jats:p>","DOI":"10.1111\/gbb.12311","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T10:26:54Z","timestamp":1469442414000},"page":"621-626","source":"Crossref","is-referenced-by-count":12,"title":["Cannabinoid receptor 1 (<i>CNR1<\/i>) gene variant moderates neural index of cognitive disruption during nicotine withdrawal"],"prefix":"10.1111","volume":"15","author":[{"given":"D. E.","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Health Outcomes and Behavior Moffitt Cancer Center  Tampa FL USA"},{"name":"Departments of Oncologic Sciences &amp; Psychology University of South Florida  Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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