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The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin\u2010<jats:styled-content style=\"fixed-case\">A5<\/jats:styled-content>, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin\u2010<jats:styled-content style=\"fixed-case\">A5<\/jats:styled-content>\n<jats:sup>\u2212\/\u2212<\/jats:sup> mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin\u2010<jats:styled-content style=\"fixed-case\">A5<\/jats:styled-content> plays a key role in the development and\/or function of neural pathways mediating mouse maternal care and anxiety.<\/jats:p>","DOI":"10.1111\/gbb.12319","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T07:56:59Z","timestamp":1471507019000},"page":"271-284","source":"Crossref","is-referenced-by-count":20,"title":["Decreased maternal behavior and anxiety in ephrin\u2010A5<sup>\u2212\/\u2212<\/sup> mice"],"prefix":"10.1111","volume":"16","author":[{"given":"M.","family":"Sheleg","sequence":"first","affiliation":[{"name":"Departments of Chemical Biology, Susan Lehman\u2010Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy Rutgers University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Yu","sequence":"additional","affiliation":[{"name":"Departments of Chemical Biology, Susan Lehman\u2010Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy Rutgers University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Go","sequence":"additional","affiliation":[{"name":"Departments of Chemical Biology, Susan Lehman\u2010Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy Rutgers University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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