{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:37:54Z","timestamp":1790469474371,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT2013\u20100653"],"award-info":[{"award-number":["PICT2013\u20100653"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACyT 2014\u2010011"],"award-info":[{"award-number":["UBACyT 2014\u2010011"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 2012\u2010476"],"award-info":[{"award-number":["PIP 2012\u2010476"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Perinatal development represents a critical period in the life of an individual. A common cause of poor development is that which comes from undernutrition or malnutrition. In particular, protein deprivation during development has been shown to have deep deleterious effects on brain's growth and plasticity. Early\u2010life stress has also been linked with an increased risk to develop different psychopathologies later in life. We have previously shown that perinatal protein malnutrition in mice leads to the appearance of anxiety\u2010related behaviors in the adulthood. We also found evidence that the female offspring was more susceptible to the development of depression\u2010related behaviors. In the present work, we further investigated this behavior together with its molecular bases. We focused our study on the hippocampus, as it is a structure involved in coping with stressful situations. We found an increase in immobility time in the forced swimming test in perinatally malnourished females, and an alteration in the expression of genes related with neuroplasticity, early growth response 1, calcineurin and c\u2010fos. We also found that perinatal malnutrition causes a reduction in the number of neurons in the hippocampus. This reduction, together with altered gene expression, could be related to the increment in immobility time observed in the forced swimming test.<\/jats:p>","DOI":"10.1111\/gbb.12322","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T07:58:44Z","timestamp":1472025524000},"page":"741-749","source":"Crossref","is-referenced-by-count":23,"title":["Altered gene expression in hippocampus and depressive\u2010like behavior in young adult female mice by early protein malnutrition"],"prefix":"10.1111","volume":"15","author":[{"given":"L. M.","family":"Belluscio","sequence":"first","affiliation":[{"name":"Laboratorio de Neuroepigen\u00e9tica, Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas  Ciudad de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D.","family":"Alberca","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroepigen\u00e9tica, Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Pregi","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroepigen\u00e9tica, Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas  Ciudad de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. T.","family":"C\u00e1nepa","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroepigen\u00e9tica, Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas  Ciudad de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.03.009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2006.06.031"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00005-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.07.004"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4112"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.02.051"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.01934.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.012809.104751"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2015.00156"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2009.00265.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.05.002"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.11.030"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2015.11.001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.08.019"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860600847061"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2009.01380.x"},{"key":"e_1_2_5_18_1","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin K.B.J.","year":"2007"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22334"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2010.02208.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00766-2"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.10.047"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.09.009"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1104383108"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00021"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(96)00021-4"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-4-31"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308240110"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13367"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.07.037"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8020590"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00164-9"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2639"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0337481100"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.10.046"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.03.025"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.08.071"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00048"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4086"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366057"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.06.005"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.03.009"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1432926100"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(02)00012-X"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.03.026"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00334-5"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90262-3"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.002"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.11.1939"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00005"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2011.10.002"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.03.018"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp045"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.02.012"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1969"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3283477ad5"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.04.016"},{"key":"e_1_2_5_58_1","first-page":"89","volume-title":"Progress in Molecular Biology and Translational Science","author":"Veyrac A.","year":"2014"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e31820b7707"},{"key":"e_1_2_5_60_1","unstructured":"World Health Organization. (2012) Global burden of disease. URLhttp:\/\/www.who.int\/healthinfo\/global_burden_disease\/gbd\/en\/(Date of last access 2 January 2016)."},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1647"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07285.x"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgbb.12322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgbb.12322","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:38:35Z","timestamp":1696340315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,27]]},"references-count":61,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/gbb.12322"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12322","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,27]]}}}