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There is limited knowledge about the underlying neuropathophysiology contributing to these behaviors. Previous findings suggest that central<jats:styled-content style=\"fixed-case\">5HT<jats:sub>2A<\/jats:sub><\/jats:styled-content>receptor activity is altered in autism, while recent work indicates that systemic<jats:styled-content style=\"fixed-case\">5HT<jats:sub>2A<\/jats:sub><\/jats:styled-content>receptor antagonist treatment reduces repetitive behaviors in an idiopathic model of autism.<jats:styled-content style=\"fixed-case\">5HT<jats:sub>2A<\/jats:sub><\/jats:styled-content>receptors are expressed in the orbitofrontal cortex and striatum. These two regions have been shown to be altered in autism. The present study investigated whether<jats:styled-content style=\"fixed-case\">5HT<jats:sub>2A<\/jats:sub><\/jats:styled-content>receptor blockade in the dorsomedial striatum or orbitofrontal cortex in the<jats:styled-content style=\"fixed-case\">BTBR<\/jats:styled-content>mouse strain, an idiopathic model of autism, affects the phenotype related to restricted and repetitive behaviors. Microinfusion of the<jats:styled-content style=\"fixed-case\">5HT<jats:sub>2A<\/jats:sub><\/jats:styled-content>receptor antagonist,<jats:styled-content style=\"fixed-case\">M100907<\/jats:styled-content>into the dorsomedial striatum alleviated a reversal learning impairment and attenuated grooming behavior.<jats:styled-content style=\"fixed-case\">M100907<\/jats:styled-content>infusion into the orbitofrontal cortex increased perseveration during reversal learning and potentiated grooming. These findings suggest that increased<jats:styled-content style=\"fixed-case\">5HT<jats:sub>2A<\/jats:sub><\/jats:styled-content>receptor activity in the dorsomedial striatum may contribute to behavioral inflexibility and stereotyped behaviors in the<jats:styled-content style=\"fixed-case\">BTBR<\/jats:styled-content>mouse.<jats:styled-content style=\"fixed-case\">5HT<jats:sub>2A<\/jats:sub><\/jats:styled-content>receptor signaling in the orbitofrontal cortex may be critical for inhibiting a previously learned response during reversal learning and expression of stereotyped behavior. The present results suggest which brain areas exhibit abnormalities underlying repetitive behaviors in an idiopathic mouse model of autism, as well as which brain areas systemic treatment with<jats:styled-content style=\"fixed-case\">M100907<\/jats:styled-content>may principally act on in<jats:styled-content style=\"fixed-case\">BTBR<\/jats:styled-content>mice to attenuate repetitive behaviors.<\/jats:p>","DOI":"10.1111\/gbb.12343","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T15:52:58Z","timestamp":1474559578000},"page":"342-351","source":"Crossref","is-referenced-by-count":51,"title":["<scp>5HT<sub>2A<\/sub><\/scp>receptor blockade in dorsomedial striatum reduces repetitive behaviors in<scp>BTBR<\/scp>mice"],"prefix":"10.1111","volume":"16","author":[{"given":"D. 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