{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:11:34Z","timestamp":1696320694562},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 104\u20102320\u2010B\u2010040\u2010014"],"award-info":[{"award-number":["MOST 104\u20102320\u2010B\u2010040\u2010014"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Phenylpropanolamine (<jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content>)\u2010induced appetite control is associated with oxidative stress in the hypothalamus. This study explored whether hypothalamic antioxidants participated in hypothalamic ghrelin system\u2010associated appetite control in <jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content>\u2010treated rats. Rats were given <jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content> daily for 4\u2009days, and changes in food intake and the expression of neuropeptide Y (<jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>), the cocaine\u2010 and amphetamine\u2010regulated transcript (<jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content>), superoxide dismutase, catalase, ghrelin, acyl ghrelin (<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>), ghrelin <jats:italic>O<\/jats:italic>\u2010acyltransferase (<jats:styled-content style=\"fixed-case\">GOAT<\/jats:styled-content>) and the ghrelin receptor (<jats:styled-content style=\"fixed-case\">GHSR1a<\/jats:styled-content>) were examined and compared. Results showed that both food intake and the expression of <jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content> and ghrelin\/<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GOAT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GHSR1a<\/jats:styled-content> decreased in response to <jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content> treatment with maximum decrease on Day 2 of the treatment. In contrast, the expression of antioxidants and <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content> increased, with the maximum increase on Day 2, with the expression opposite to that of <jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content> and ghrelin. A cerebral infusion of either a <jats:styled-content style=\"fixed-case\">GHSR1a<\/jats:styled-content> antagonist or reactive oxygen species scavenger modulated feeding behavior and <jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content>, antioxidants and ghrelin system expression, showing the involvement of ghrelin signaling and oxidative stress in regulating <jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content>\u2010mediated appetite control. We suggest that hypothalamic ghrelin signaling system, with the help of antioxidants, may participate in <jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content>\u2010mediated appetite control in <jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content>\u2010treated rats.<\/jats:p>","DOI":"10.1111\/gbb.12360","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T14:12:55Z","timestamp":1478614375000},"page":"439-448","source":"Crossref","is-referenced-by-count":1,"title":["Mediation of oxidative stress in hypothalamic ghrelin\u2010associated appetite control in rats treated with phenylpropanolamine"],"prefix":"10.1111","volume":"16","author":[{"given":"C.\u2010H.","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Physiology Chung Shan Medical University and Chung Shan Medical University Hospital  Taichung City 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