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The nociceptin\u2010<jats:styled-content style=\"fixed-case\">NOP<\/jats:styled-content>receptor system is one of the major systems involved in pain control and much evidence also suggested its implication in stress, anxiety and depression. Therefore, we investigated the nociceptin\u2010<jats:styled-content style=\"fixed-case\">NOP<\/jats:styled-content>system alterations in selected brain regions in a neuropathic pain murine model. Fourteen days after the common sciatic nerve ligature, polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) analysis indicated a significant decrease of pronociceptin and<jats:styled-content style=\"fixed-case\">NOP<\/jats:styled-content>receptor<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>levels in the thalamus; these alterations could contribute to the decrease of the thalamic inhibitory function reported in neuropathic pain condition. Nociceptin peptide and<jats:styled-content style=\"fixed-case\">NOP mRNA<\/jats:styled-content>increased in the anterior cingulate cortex (<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>) and not in the somatosensory cortex, suggesting a peculiar involvement of this system in pain regulating circuitry. Similarly to the<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>, an increase of nociceptin peptide levels was observed in the amygdala. Finally, the pronociceptin and<jats:styled-content style=\"fixed-case\">NOP mRNAs<\/jats:styled-content>decrease observed in the hypothalamus reflects the lack of hypothalamus\u2010pituitary\u2010adrenal axis activation, already reported in neuropathic pain models. Our data indicate that neuropathic pain conditions affect the supraspinal nociceptin\u2010<jats:styled-content style=\"fixed-case\">NOP<\/jats:styled-content>system which is also altered in regions known to play a role in emotional aspects of pain.<\/jats:p>","DOI":"10.1111\/gbb.12365","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T11:36:49Z","timestamp":1482320209000},"page":"537-545","source":"Crossref","is-referenced-by-count":13,"title":["N\/<scp>OFQ<\/scp>system in brain areas of nerve\u2010injured mice: its role in different aspects of neuropathic pain"],"prefix":"10.1111","volume":"16","author":[{"given":"M.","family":"Palmisano","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Biotechnology Alma Mater Studiorum \u2010 University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mercatelli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology Alma Mater Studiorum \u2010 University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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