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Alterations in the synthesis and secretion of melatonin have been reported in various mood disorders, including major depressive disorder. However, the role of endogenous melatonin in the pathophysiology of depressive disorder is unclear. Melatonin primarily acts through two G protein\u2010coupled receptors, termed <jats:styled-content style=\"fixed-case\">MT<jats:sub>1<\/jats:sub><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MT<jats:sub>2<\/jats:sub><\/jats:styled-content>. The present study investigated the effect of genetic deletion of the <jats:styled-content style=\"fixed-case\">MT<jats:sub>1<\/jats:sub><\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">MT<jats:sub>2<\/jats:sub><\/jats:styled-content> receptors on tests associated with depression\u2010 and anxiety\u2010like behaviors in <jats:styled-content style=\"fixed-case\">C3H<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HeN<\/jats:styled-content> mice. Deletion of the <jats:styled-content style=\"fixed-case\">MT<jats:sub>1<\/jats:sub><\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">MT<jats:sub>2<\/jats:sub><\/jats:styled-content> receptors caused a deficit in hedonic and social interaction behavior, and increased anxiety\u2010like behavior. It is likely that dysregulations of the <jats:styled-content style=\"fixed-case\">MT<jats:sub>1<\/jats:sub><\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">MT<jats:sub>2<\/jats:sub><\/jats:styled-content> melatonin receptors could be involved in the pathophysiology of depression and anxiety.<\/jats:p>","DOI":"10.1111\/gbb.12369","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T22:04:40Z","timestamp":1486159480000},"page":"546-553","source":"Crossref","is-referenced-by-count":52,"title":["Role of the <scp>MT<sub>1<\/sub><\/scp> and <scp>MT<sub>2<\/sub><\/scp> melatonin receptors in mediating depressive\u2010 and anxiety\u2010like behaviors in <scp>C3H<\/scp>\/<scp>HeN<\/scp> mice"],"prefix":"10.1111","volume":"16","author":[{"given":"J.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences University at Buffalo (SUNY)  Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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