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Furthermore, characterization of hearing ability in mouse models is needed to ensure that tests of cognition that use auditory stimuli are not confounded by hearing dysfunction. Therefore, we assessed acoustic startle response and pre\u2010pulse inhibition in the double transgenic<jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content>mouse model of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>from 3\u20134 to 16\u2009months of age. The<jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content>mice showed an age\u2010related decline in acoustic startle as early as 3\u20134\u2009months of age. We subsequently tested auditory brainstem response (<jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>) thresholds at 4 and 13\u201314\u2009months of age using tone bursts at frequencies of 2\u201332\u2009<jats:styled-content style=\"fixed-case\">kHz<\/jats:styled-content>. The<jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content>mice showed increased<jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>thresholds for tone bursts between 8 and 32\u2009<jats:styled-content style=\"fixed-case\">kHz<\/jats:styled-content>at 13\u201314\u2009months of age. Finally, cochleae were extracted and basilar membranes were dissected to count hair cell loss across the cochlea. The<jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content>mice showed significantly greater loss of both inner and outer hair cells at the apical and basal ends of the basilar membrane than wild\u2010type mice at 15\u201316\u2009months of age. These results indicate that the<jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content>mouse model of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>shows age\u2010related decreases in acoustic startle responses, which are at least partially due to age\u2010related peripheral hearing loss. Therefore, we caution against the use of cognitive tests that rely on audition in<jats:styled-content style=\"fixed-case\">5xFAD<\/jats:styled-content>mice over 3\u20134\u2009months of age, without first confirming that performance is not confounded by hearing dysfunction.<\/jats:p>","DOI":"10.1111\/gbb.12370","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T04:02:44Z","timestamp":1485748964000},"page":"554-563","source":"Crossref","is-referenced-by-count":79,"title":["Reduced acoustic startle response and peripheral hearing loss in the<scp>5xFAD<\/scp>mouse model of Alzheimer's disease"],"prefix":"10.1111","volume":"16","author":[{"given":"T. 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