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In a new Floxed<jats:italic>Pde1b<\/jats:italic>\u2009\u00d7\u2009<jats:styled-content style=\"fixed-case\">Cre<jats:sup>CMV<\/jats:sup><\/jats:styled-content>global knockout (<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>) mouse model, we show an immobility\u2010resistance phenotype that recapitulates that found in constitutive<jats:italic>Pde1b<\/jats:italic><jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>mice. We use this new mouse model to show that the resistance to acute stress\u2010induced depression\u2010like phenotype is not the product of changes in locomotor activity or reactivity to other stressors (learned helplessness, novelty suppressed feeding or dexamethasone suppression), and is not associated with anhedonia using the sucrose preference test. Using tamoxifen inducible Cre, we show that the immobility\u2010resistant phenotype depends on the age of induction. The effect is present when<jats:italic>Pde1b<\/jats:italic>is Reduced from conception,<jats:styled-content style=\"fixed-case\">P0<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">P32<\/jats:styled-content>, but not if reduced as adults (<jats:styled-content style=\"fixed-case\">P60<\/jats:styled-content>). We also mapped regional brain expression of<jats:styled-content style=\"fixed-case\">PDE1B<\/jats:styled-content>protein and of the Cre driver. These data add to the suggestion that<jats:styled-content style=\"fixed-case\">PDE1B<\/jats:styled-content>may be a target for drug development with therapeutic potential in depression alone or in combination with existing antidepressants.<\/jats:p>","DOI":"10.1111\/gbb.12391","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T08:06:49Z","timestamp":1494403609000},"page":"756-767","source":"Crossref","is-referenced-by-count":12,"title":["Phosphodiesterase\u20101b deletion confers depression\u2010like behavioral resistance separate from stress\u2010related effects in mice"],"prefix":"10.1111","volume":"16","author":[{"given":"J. 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