{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:02:52Z","timestamp":1789192972296,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH099251"],"award-info":[{"award-number":["MH099251"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004866","name":"New York State Office of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>In the mouse, a powerful paradigm of early life stress, infant maternal separation (<jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content>), can trigger emotional and cognitive dysfunctions in adulthood similar to those found in humans with a history of childhood adversity. The magnitude of <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content> effects differs among diverse inbred strains suggesting an interaction between the genetic background of pups and the maternal care they received. Here, we investigated this interaction with studies on reciprocal <jats:styled-content style=\"fixed-case\">F1<\/jats:styled-content> hybrid mice of the stress\u2010susceptible Balb\/c and the resilient <jats:styled-content style=\"fixed-case\">C57Bl<\/jats:styled-content>\/6 strains that were either raised by Balb\/c mothers (low maternal care) or by <jats:styled-content style=\"fixed-case\">C57Bl<\/jats:styled-content>\/6 mothers (higher maternal care) with or without <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content> exposure. The ultrasonic vocalization response to isolation was recorded from infant <jats:styled-content style=\"fixed-case\">F1<\/jats:styled-content> pups, and their emotional, executive cognitive and epigenetic phenotypes were assessed in adulthood. These studies showed that, regardless of the maternal care received, the emotional phenotype of <jats:styled-content style=\"fixed-case\">F1<\/jats:styled-content> hybrids was not significantly affected by <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content> exposure. However, <jats:styled-content style=\"fixed-case\">F1<\/jats:styled-content> pups raised by Balb\/c (but not <jats:styled-content style=\"fixed-case\">C57Bl<\/jats:styled-content>\/6) mothers during <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content> exposure exhibit deficits in working memory and attention\u2010set\u2010shifting in adulthood. They also exhibit reduced histone deacetylase 1 levels at promotors of brain\u2010derived neurotrophic factor and early growth response 2 genes, and abnormally high induction of expression of these genes during cognitive testing. As one of affected genes was previously shown to associate with the Balb\/c and the other with the <jats:styled-content style=\"fixed-case\">C57Bl<\/jats:styled-content>\/6 genetic background, these findings indicate that both parental alleles interact with the maternal environment to modulate the cognitive and epigenetic phenotypes of <jats:styled-content style=\"fixed-case\">F1<\/jats:styled-content> mice exposed to the <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/gbb.12395","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T08:28:45Z","timestamp":1496132925000},"page":"768-780","source":"Crossref","is-referenced-by-count":23,"title":["Lasting effects of early life stress in mice: interaction of maternal environment and infant genes"],"prefix":"10.1111","volume":"16","author":[{"given":"A. J.","family":"Feifel","sequence":"first","affiliation":[{"name":"Department of Psychiatry Columbia University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. N.","family":"Shair","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University  New York NY USA"},{"name":"Division of Developmental Neuroscience New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-5110","authenticated-orcid":false,"given":"C.","family":"Schmauss","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University  New York NY USA"},{"name":"Division of Molecular Therapeutics New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.05.018"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0736-5748(98)00025-2","article-title":"Do early\u2010life events permanently alter behavioral and hormonal responses to stressors?","volume":"3","author":"Anisman H.","year":"1998","journal-title":"Int J Dev Neurosci"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072290"},{"key":"e_1_2_5_5_1","first-page":"104","article-title":"Pups call, mothers rush: does maternal responsiveness affect the amount of ultrasonic vocalization in mouse pups?","volume":"35","author":"D'Amato F.R.","year":"2005","journal-title":"Behav Genet"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.012"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1038"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.10.032"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(03)00028-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20577"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13811118.2010.524025"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.09.005"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22063"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.05.003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0021952"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3628"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.05.003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.019"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2336126100"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2009-2"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(93)90189-V"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08171"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep04873"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.02.016"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.08.013"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-004-0857-4"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.06.021"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.09.012"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgbb.12395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T10:42:21Z","timestamp":1695724941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/gbb.12395"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12395","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]}}}