{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:33:57Z","timestamp":1791408837098,"version":"4.3.3"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    To expand, analyze and extend published behavioral phenotypes relevant to autism spectrum disorder (ASD), we present a study of three ASD genetic mouse models: Feng's\n                    <jats:italic>Shank3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>tm2Gfng<\/jats:italic>\n                    <\/jats:sup>\n                    model, hereafter\n                    <jats:italic>Shank3\/F<\/jats:italic>\n                    , Jiang's\n                    <jats:italic>Shank3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>tm1Yhj<\/jats:italic>\n                    <\/jats:sup>\n                    model, hereafter\n                    <jats:italic>Shank3\/J<\/jats:italic>\n                    and the Cacna1c deletion model. The\n                    <jats:italic>Shank3<\/jats:italic>\n                    models mimick gene mutations associated with Phelan\u2013McDermid Syndrome and the Cacna1c model recapitulates the deletion underlying Timothy syndrome. This study utilizes both standard and novel behavioral tests with the same methodology used in our previously published companion report on the\n                    <jats:italic>Cntnap2<\/jats:italic>\n                    null and 16p11.2 deletion models. We found that some but not all behaviors replicated published findings and those that did replicate, such as social behavior and overgrooming in\n                    <jats:italic>Shank3<\/jats:italic>\n                    models, tended to be milder than reported elsewhere. The\n                    <jats:italic>Shank3\/F<\/jats:italic>\n                    model, and to a much lesser extent, the\n                    <jats:italic>Shank3\/J<\/jats:italic>\n                    and Cacna1c models, showed hypoactivity and a general anxiety\u2010like behavior triggered by external stimuli which pervaded social interactions. We did not detect deficits in a cognitive procedural learning test nor did we observe perseverative behavior in these models. We did, however, find differences in exploratory patterns of Cacna1c mutant mice suggestive of a behavioral effect in a social setting. In addition, only\n                    <jats:italic>Shank3\/F<\/jats:italic>\n                    showed differences in sensory\u2010gating. Both positive and negative results from this study will be useful in identifying the most robust and replicable behavioral signatures within and across mouse models of autism. Understanding these phenotypes may shed light of which features to study when screening compounds for potential therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12405","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T11:42:39Z","timestamp":1501242159000},"page":"4-22","source":"Crossref","is-referenced-by-count":54,"title":["Comprehensive analysis of two\n                    <i>Shank3<\/i>\n                    and the Cacna1c mouse models of autism spectrum disorder"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3305-0795","authenticated-orcid":false,"given":"P.A.","family":"Kabitzke","sequence":"first","affiliation":[{"name":"PsychoGenics, Inc  Tarrytown NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Brunner","sequence":"additional","affiliation":[{"name":"PsychoGenics, Inc  Tarrytown NY USA"},{"name":"Department of Psychiatry Columbia 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