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However, motor, sensory and\/or health issues consequent to the mutation may introduce artifacts that preclude testing in some standard cognitive assays. Touchscreen learning and memory tasks in small operant chambers have the potential to circumvent these confounds. Here we use touchscreen visual discrimination learning to evaluate performance in the maternally derived <jats:italic>Ube3a<\/jats:italic> mouse model of Angelman syndrome, the Ts65Dn trisomy mouse model of Down syndrome, and the <jats:italic>Mecp2<\/jats:italic><jats:sup><jats:italic>Bird<\/jats:italic><\/jats:sup> mouse model of Rett syndrome. Significant deficits in acquisition of a 2\u2010choice visual discrimination task were detected in both <jats:italic>Ube3a<\/jats:italic> and Ts65Dn mice. Procedural control measures showed no genotype differences during pretraining phases or during acquisition. <jats:italic>Mecp2<\/jats:italic> males did not survive long enough for touchscreen training, consistent with previous reports. Most <jats:italic>Mecp2<\/jats:italic> females failed on pretraining criteria. Significant impairments on Morris water maze spatial learning were detected in both <jats:italic>Ube3a<\/jats:italic> and Ts65Dn, replicating previous findings. Abnormalities on rotarod in <jats:italic>Ube3a<\/jats:italic>, and on open field in Ts65Dn, replicating previous findings, may have contributed to the observed acquisition deficits and swim speed abnormalities during water maze performance. In contrast, these motor phenotypes do not appear to have affected touchscreen procedural abilities during pretraining or visual discrimination training. Our findings of slower touchscreen learning in 2 mouse models of neurodevelopmental disorders with intellectual disabilities indicate that operant tasks offer promising outcome measures for the preclinical discovery of effective pharmacological therapeutics.<\/jats:p>","DOI":"10.1111\/gbb.12452","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T15:49:37Z","timestamp":1513784977000},"source":"Crossref","is-referenced-by-count":26,"title":["Touchscreen learning deficits in <i>Ube3a<\/i>, Ts65Dn and <i>Mecp2<\/i> mouse models of neurodevelopmental disorders with intellectual disabilities"],"prefix":"10.1111","volume":"17","author":[{"given":"P. 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