{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:15:09Z","timestamp":1780406109506,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["016.165.397"],"award-info":[{"award-number":["016.165.397"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>About 1 in 650 boys are born with an extra X chromosome (47,XXY or Klinefelter syndrome). 47,XXY is associated with vulnerabilities in socio\u2010emotional development. This study was designed to assess types of cognitive deficits in individuals with 47,XXY that may contribute to social\u2010emotional dysfunction, and to evaluate the nature of such deficits at various levels: ranging from basic visuospatial processing deficits, impairments in face recognition (FR), to emotion expression impairments. A total of 70 boys and men with 47,XXY, aged 8 to 60\u2009years old, participated in the study. The subtests feature identification, FR and identification of facial emotions of the Amsterdam Neuropsychological Tasks were used. Level of intellectual functioning was assessed with the child and adult versions of the Wechsler Intelligence Scales. Reaction time data showed that in the 47,XXY group, 17% had difficulties in visuospatial processing (no social load), 26% had difficulties with FR (medium social load) and an even higher number of 33% had difficulties with facial expressions of emotions (high\u2010social load). Information processing impairments increased as a function of \u201csocial load\u201d of the stimuli, independent of intellectual functioning. Taken together, our data suggest that on average individuals with XXY may have more difficulties in information processing when \u201csocial load\u201d increases, suggesting a specific difficulty in the higher\u2010order labeling and interpretation of social cues, which cannot be explained by more basic visuospatial perceptual skills. Considering the increased risk for social cognitive impairments, routine assessment of social cognitive functioning as part of neuropsychological screening is warranted.<\/jats:p>","DOI":"10.1111\/gbb.12465","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T15:56:36Z","timestamp":1517932596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The nature of social cognitive deficits in children and adults with Klinefelter syndrome (47,XXY)"],"prefix":"10.1111","volume":"17","author":[{"given":"S.","family":"van Rijn","sequence":"first","affiliation":[{"name":"Clinical Child and Adolescent Studies Leiden University  Leiden The Netherlands"},{"name":"Leiden Institute for Brain and Cognition  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"de Sonneville","sequence":"additional","affiliation":[{"name":"Clinical Child and Adolescent Studies Leiden University  Leiden The Netherlands"},{"name":"Leiden Institute for Brain and Cognition  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Swaab","sequence":"additional","affiliation":[{"name":"Clinical Child and Adolescent Studies Leiden University  Leiden The Netherlands"},{"name":"Leiden Institute for Brain and Cognition  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021491"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-013-1860-5"},{"issue":"1","key":"e_1_2_5_4_1","first-page":"151","article-title":"The spectrum of the behavioral phenotype in boys and adolescents 47,XXY (Klinefelter syndrome)","volume":"8","author":"Tartaglia N","year":"2010","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2012.02.013"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12134"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005581"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707071044"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.02.020"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000302"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084721"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15326942dn2703_6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096-3445.115.2.107"},{"key":"e_1_2_5_14_1","volume-title":"WISC\u2010III NL Wechsler Intelligence for Children (David Wechsler)","author":"Kort W","year":"2005"},{"key":"e_1_2_5_15_1","volume-title":"WAIS\u2010III NL. Wechsler Adult Intelligence Scale WAIS\u2010III","author":"Wechsler D","year":"2005"},{"key":"e_1_2_5_16_1","volume-title":"Cognitive Ergonomics, Clinical Assessment and Computer\u2010Assisted Learning: Computers in Psychology","author":"De Sonneville LMJ","year":"1999"},{"key":"e_1_2_5_17_1","first-page":"27","article-title":"Amsterdamse Neuropsychologische Taken: wetenschappelijke en klinische toepassingen","volume":"0","author":"De Sonneville L","year":"2005","journal-title":"Tijdschr Voor Neuropsychol"},{"key":"e_1_2_5_18_1","volume-title":"Handbook Amsterdam Neuropsychological Tasks","author":"De Sonneville LS","year":"2014"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.24.2.200.989"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2012.08.024"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1443"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007870170050"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-013-1807-x"},{"key":"e_1_2_5_24_1","first-page":"257","article-title":"Recognition of facial emotion and affective prosody in children with ASD (+ADHD) and their unaffected siblings","volume":"23","author":"Oerlemans AM","year":"2014","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024458618172"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000246"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scog.2015.01.001"},{"key":"e_1_2_5_28_1","volume-title":"Neuropsychological Assessment","author":"Lezak MD","year":"2004"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00202-6"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu174"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2009.09.006"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0719"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0000000000000429"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgbb.12465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:13:13Z","timestamp":1695010393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,22]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/gbb.12465"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12465","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,22]]},"assertion":[{"value":"2017-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12465"}}