{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:33:29Z","timestamp":1753878809197,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["G0400577"],"award-info":[{"award-number":["G0400577"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000836","name":"University of Liverpool","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Monoamine oxidase\u2010A (MAOA) metabolises monoamines and is implicated in the pathophysiology of psychiatric disorders. A polymorphic repetitive DNA domain, termed the uVNTR (upstream variable number tandem repeat), located at the promoter of the <jats:italic>MAOA<\/jats:italic> gene is a risk factor for many of these disorders. MAOA is on the X chromosome suggesting gender could play a role in regulation. We analysed MAOA regulation in the human female cell line, SH\u2010SY5Y, which is polymorphic for the uVNTR. This heterozygosity allowed us to correlate allele\u2010specific gene expression with allele\u2010specific transcription factor binding and epigenetic marks for MAOA. Gene regulation was analysed under basal conditions and in response to the mood stabiliser sodium valproate. Both alleles were transcriptionally active under basal growth conditions; however, the alleles showed distinct transcription factor binding and epigenetic marks at their respective promoters. Exposure of the cells to sodium valproate resulted in differential allelic expression which correlated with allele\u2010specific changes in distinct transcription factor binding and epigenetic marks at the region encompassing the uVNTR. Biochemically our model for MAOA promoter function has implications for gender differences in gene \u00d7 environment responses in which the uVNTR has been implicated as a genetic risk.<\/jats:p>","DOI":"10.1111\/gbb.12483","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T07:41:28Z","timestamp":1524037288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Distinct chromatin structures at the monoamine oxidase\u2010A promoter correlate with allele\u2010specific expression in SH\u2010SY5Y cells"],"prefix":"10.1111","volume":"18","author":[{"given":"M.","family":"Manca","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine University of Liverpool  Liverpool UK"},{"name":"Institute of Psychology, Health and Society University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine University of Liverpool  Liverpool UK"},{"name":"Institute of Psychology, Health and Society University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pickles","sequence":"additional","affiliation":[{"name":"King's College London, MRC Social Genetic and Developmental Psychiatry Research Centre Institute of Psychiatry  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hill","sequence":"additional","affiliation":[{"name":"School for Psychology and Clinical Language Sciences University of Reading  Reading UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sharp","sequence":"additional","affiliation":[{"name":"Institute of Psychology, Health and Society University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Murgatroyd","sequence":"additional","affiliation":[{"name":"School of Healthcare Science Manchester Metropolitan University  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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