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The aim of this study was to investigate excessive habit formation by analyzing the SIP licking microstructure among rat strains, and to compare the brain areas activated by SIP in different populations. Wistar, Long Evans and Roman High\u2010 and Low\u2010Avoidance rat strains were compared using a cluster analysis of 2 main variables, that is, frequency of licking (percentage of interpellet intervals with drinking episodes) and intensity of licking (mean number of licks per interpellet interval), and were found to exhibit high intensity and frequent licking (compulsive drinkers, CD), low intensity but frequent licking (habitual drinkers, HD), and low intensity and low\u2010frequency licking (low drinkers, LD). The Wistar strain showed a higher frequency and intensity of licking, and had the largest group of CD rats when compared with the other strains. Regarding the acquisition of SIP, CD rats showed a higher intensity of licking when compared with the HD and LD rats. Moreover, c\u2010Fos quantification revealed that rats in the CD group showed hyperactivity in the lateral orbitofrontal cortex and basolateral amygdala when compared with the LD group. Analyzing the SIP microstructure could be a valuable tool for understanding the role of excessive habit formation in the development of compulsive drinking and its underpinning neurobiological mechanisms.<\/jats:p>","DOI":"10.1111\/gbb.12489","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T08:51:35Z","timestamp":1528361495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Excessive habit formation in schedule\u2010induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex"],"prefix":"10.1111","volume":"18","author":[{"given":"A.","family":"Merch\u00e1n","sequence":"first","affiliation":[{"name":"Department of Psychology and CIAMBITAL University of Almer\u00eda &amp; CeiA3  Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mora","sequence":"additional","affiliation":[{"name":"Department of Psychology and CIAMBITAL University of Almer\u00eda &amp; CeiA3  Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gago","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Science University of M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rodriguez\u2010Ortega","sequence":"additional","affiliation":[{"name":"Department of Psychology and CIAMBITAL University of Almer\u00eda &amp; CeiA3  Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fern\u00e1ndez\u2010Teruel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Forensic Medicine Institute of Neurosciences, School of Medicine, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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