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C56BL\/6N mice that no longer express VGLUT3 (VGLUT3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) display anxiety\u2010associated phenotype, increased spontaneous and cocaine\u2010induced locomotor activity and decreased haloperidol\u2010induced catalepsy. Inbred mouse strains differ markedly in their sensitivity to anxiety and behavioral responses elicited by drugs. The purpose of this study was to investigate strain differences in VGLUT3 expression levels and its potential correlates with anxiety and reward\u2010guided behaviors. Five inbred mouse lines were chosen according to their contrasted anxiety and drugs sensitivity: C57BL\/6N, C3H\/HeN, DBA\/2J, 129\/Sv, and BALB\/c. VGLUT3 protein expression was measured in different brain areas involved in reward or mood regulation (such as the striatum, the hippocampus, and raphe nuclei) and genetic variations in\n                    <jats:italic>Slc17a8<\/jats:italic>\n                    , the gene encoding for VGLUT3, have been explored. These five inbred mouse strains express very different levels of VGLUT3, which cannot be attributed to the genetic variation of the\n                    <jats:italic>Slc17a8<\/jats:italic>\n                    locus. Furthermore, mice behavior in the open field, elevated plus maze, spontaneous\u2010 and cocaine\u2010induced locomotor was highly heterogeneous and only partially correlated to VGLUT3 levels. These data highlight the fact that one single gene polymorphism could not account for VGLUT3 expression variations, and that region specific VGLUT3 expression level variations might play a key role in the modulation of discrete behaviors.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12528","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T01:13:27Z","timestamp":1539652407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Differential expression of VGLUT3 in laboratory mouse strains: Impact on drug\u2010induced hyperlocomotion and anxiety\u2010related behaviors"],"prefix":"10.1111","volume":"18","author":[{"given":"Diana Y.","family":"Sakae","sequence":"first","affiliation":[{"name":"INSERM, CNRS, Neuroscience Paris Seine\u2014Institut de Biologie Paris Seine (NPS\u2010IBPS) Sorbonne Universit\u00e9 Paris 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