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The distribution of OXTR in the brain can profoundly influence social behavior. Emerging evidence suggests that DNA methylation of <jats:italic>OXTR<\/jats:italic> influences <jats:italic>OXTR<\/jats:italic> expression. Previously, we conducted a pharmaco\u2010functional Magnetic Resonance Imaging (fMRI) study in which healthy subjects were randomized to 24\u2009IU intranasal OT or placebo and imaged with fMRI while playing a dyadic social interaction task known as the iterated Prisoner's Dilemma (PD) game with same\u2010sex partners. Here, we investigate whether DNA methylation of <jats:italic>OXTR<\/jats:italic> modulates the effect of intranasal OT on the neural response to positive and negative social interactions in the PD game. <jats:italic>OXTR<\/jats:italic> methylation did not modulate OT effects within brain regions where we previously reported OT effects in response to reciprocated (caudate nucleus) and unreciprocated cooperation (amygdala and anterior insula). However, <jats:italic>OXTR<\/jats:italic> methylation did modulate OT effects on the response to both reciprocated and unreciprocated cooperation in other brain regions such as the precuneus and visual cortex. Further restricting the analysis to <jats:italic>OXTR<\/jats:italic> rs53576 GG individuals revealed that <jats:italic>OXTR<\/jats:italic> methylation modulated OT effects on the precuneus response to reciprocated cooperation in men, the lateral septum response to reciprocated cooperation in women, and the visual cortex response to unreciprocated cooperation in men. These results suggest that <jats:italic>OXTR<\/jats:italic> methylation status may influence OT effects on mentalizing, attention and reward processing during social interactions. <jats:italic>OXTR<\/jats:italic> methylation may be important to consider if exogenous OT is used to treat social behavioral disorders in the future.<\/jats:p>","DOI":"10.1111\/gbb.12555","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T13:09:34Z","timestamp":1547039374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["<i>OXTR<\/i> methylation modulates exogenous oxytocin effects on human brain activity during social interaction"],"prefix":"10.1111","volume":"19","author":[{"given":"Xu","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Advanced Neuroimaging University of California, Riverside  Riverside California"},{"name":"Department of Anthropology Emory University  Atlanta 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