{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:53:53Z","timestamp":1790830433646,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T00:00:00Z","timestamp":1549756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEQ20150331750"],"award-info":[{"award-number":["DEQ20150331750"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201013\u2010BSV4\u20100011"],"award-info":[{"award-number":["ANR\u201013\u2010BSV4\u20100011"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>The nuclear receptor COUP TFI (also known as Nr2f1) plays major roles in specifying distinct neuronal subtypes during patterning of the neocortical motor and somatosensory cortex, as well as in regulating the longitudinal growth of the hippocampus during development. In humans, mutations in the <jats:italic>NR2F1<\/jats:italic> gene lead to a global developmental delay and intellectual disabilities. While more than 30% of patients show behavioral features of autism spectrum disorder, 16% of haploinsufficient children show signs of hyperactivity and impulsivity. Loss of COUP\u2010TFI in the cortical mouse primordium results in altered area organization and serotonin distribution, abnormal coordination of voluntary movements and learning and memory deficits. Here, we asked whether absence of COUP\u2010TFI affects locomotor activity, anxiety, as well as depression. Mice mutant for COUP\u2010TFI have normal motor coordination, but significant traits of hyperactivity, which does not seem to respond to N\u2010Methyl\u2010D\u2010aspartate (NMDA) antagonists. However, no changes in anxiety, despite increased locomotor performances, were observed in the open field task. On the contrary, elevated plus maze and dark\u2010light test explorations indicate a decreased anxiety\u2010like behavior in COUP\u2010TFI mutant mice. Finally, significantly reduced immobility in the forced swim test and no changes in anhedonia in the sucrose preference task suggest no particular depressive behaviors in mutant mice. Taken together, our study shows that loss of COUP\u2010TFI leads to increased locomotor activity but less anxiety and contributes in further deciphering the pathophysiology of patients haploinsufficient for <jats:italic>NR2F1.<\/jats:italic><\/jats:p>","DOI":"10.1111\/gbb.12556","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T19:04:25Z","timestamp":1547751865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hyperactive and anxiolytic\u2010like behaviors result from loss of COUP\u2010TFI\/Nr2f1 in the mouse cortex"],"prefix":"10.1111","volume":"18","author":[{"given":"Thomas","family":"Contesse","sequence":"first","affiliation":[{"name":"iBV \u2013 Institute of Biology Valrose Universit\u00e9 C\u00f4te d'Azur (UCA), CNRS, Inserm  Nice France"},{"name":"IPMC \u2013 Institute of Molecular and Cellular Pharmacology Universit\u00e9 C\u00f4te d'Azur (UCA), CNRS  Valbonne 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