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However, the functional role for <jats:italic>Scn4b<\/jats:italic> in ethanol\u2010mediated behaviors is unknown. We determined if genetic global knockout (KO) or targeted knockdown of <jats:italic>Scn4b<\/jats:italic> in the central nucleus of the amygdala (CeA) altered ethanol drinking or related behaviors. We used four different ethanol consumption procedures (continuous and intermittent two\u2010bottle choice (2BC), drinking\u2010in\u2010the dark and chronic intermittent ethanol vapor) and found that male and female <jats:italic>Scn4b<\/jats:italic> KO mice did not differ from their wild\u2010type (WT) littermates in ethanol consumption in any of the tests. Knockdown of <jats:italic>Scn4b<\/jats:italic> mRNA in the CeA also did not alter 2BC ethanol drinking. However, <jats:italic>Scn4b<\/jats:italic> KO mice showed longer duration of the loss of righting reflex induced by ethanol, gaboxadol, pentobarbital and ketamine. KO mice showed slower recovery to basal levels of handling\u2010induced convulsions after ethanol injection, which is consistent with the increased sedative effects observed in these mice. However, <jats:italic>Scn4b<\/jats:italic> KO mice did not differ in the severity of acute ethanol withdrawal. Acoustic startle responses, ethanol\u2010induced hypothermia and clearance of blood ethanol also did not differ between the genotypes. There were also no functional differences in the membrane properties or excitability of CeA neurons from <jats:italic>Scn4b<\/jats:italic> KO and WT mice. Although we found no evidence that <jats:italic>Scn4b<\/jats:italic> regulates ethanol consumption in mice, it was involved in the acute hypnotic effects of ethanol and other sedatives.<\/jats:p>","DOI":"10.1111\/gbb.12562","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T15:06:57Z","timestamp":1551366417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Scn4b<\/i> regulates the hypnotic effects of ethanol and other sedative drugs"],"prefix":"10.1111","volume":"18","author":[{"given":"Yuri A.","family":"Blednov","sequence":"first","affiliation":[{"name":"Waggoner Center for Alcohol and Addiction Research The University of Texas at Austin  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Bajo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla 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