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Here, we generated and behaviorally characterized female mice lacking <jats:italic>Dgkh<\/jats:italic> alone, <jats:italic>Dgki<\/jats:italic> alone, and double <jats:italic>Dgkh\/Dgki<\/jats:italic>\u2010knockout (dKO) mice. We found that fewer than 30% of newborn pups raised by dKO females survived to weaning, while over 85% of pups survived to weaning when raised by wild\u2010type (WT) females. Poor survival under the care of dKO mothers was unrelated to pup genotype. Moreover, pups from dKO dams survived when fostered by WT dams, suggesting the poor survival rate of dKO\u2010raised litters was related to impaired maternal care by dKO dams. Nest building was similar between WT and dKO dams; however, some dKO females failed to retrieve any pups in a retrieval assay. Pups raised by dKO dams had smaller or absent milk spots and reduced weight, indicative of impaired nursing. Unlike WT females, postpartum dKO females showed erratic, panicked responses to cage disturbances. Virgin dKO females showed behavioral signs of anxiety and mania, which were not seen in mice lacking either <jats:italic>Dgkh<\/jats:italic> or <jats:italic>Dgki<\/jats:italic> alone. Our research indicates that combined deletion of <jats:italic>Dgkh<\/jats:italic> and <jats:italic>Dgki<\/jats:italic> impairs maternal behavior in the early postpartum period, and suggests female dKO mice model symptoms of mania and anxiety.<\/jats:p>","DOI":"10.1111\/gbb.12570","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T10:38:04Z","timestamp":1555324684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mania\u2010 and anxiety\u2010like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice"],"prefix":"10.1111","volume":"19","author":[{"given":"Victoria B.","family":"Bartsch","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Physiology The University of North Carolina at Chapel Hill  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia 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