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We conducted GWAS of DSM\u2010IV AD (primary analysis), DSM\u2010IV AD criterion count (secondary analysis), and individual dependence criteria (tertiary analysis) among 7418 (1121 families) European American (EA) individuals from the Collaborative Study on the Genetics of Alcoholism (COGA). Trans\u2010ancestral meta\u2010analyses combined these results with data from 3175 (585 families) African\u2010American (AA) individuals from COGA. In the EA GWAS, three loci were genome\u2010wide significant: rs1229984 in ADH1B<\/jats:italic> for AD criterion count (P<\/jats:italic> = 4.16E\u221211) and Desire to cut drinking<\/jats:italic> (P<\/jats:italic> = 1.21E\u221211); rs188227250 (chromosome 8, Drinking more than intended<\/jats:italic>, P<\/jats:italic> = 6.72E\u221209); rs1912461 (chromosome 15, Time spent drinking<\/jats:italic>, P<\/jats:italic> = 1.77E\u221208). In the trans\u2010ancestral meta\u2010analysis, rs1229984 was associated with multiple phenotypes and two additional loci were genome\u2010wide significant: rs61826952 (chromosome 1, DSM\u2010IV AD, P<\/jats:italic> = 8.42E\u221211); rs7597960 (chromosome 2, Time spent drinking<\/jats:italic>, P<\/jats:italic> = 1.22E\u221208). Associations with rs1229984 and rs18822750 were replicated in independent datasets. Polygenic risk scores derived from the EA GWAS of AD predicted AD in two EA datasets (P<\/jats:italic>\u2009<\u2009.01; 0.61%\u20101.82% of variance). Identified novel variants (ie, rs1912461, rs61826952) were associated with differential central evoked theta power (loss \u2212 gain; P<\/jats:italic> = .0037) and reward\u2010related ventral striatum reactivity (P<\/jats:italic> = .008), respectively. 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