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We previously reported cognitive inflexibility in a mouse model null for the RBP CUG\u2010BP, Elav\u2010like factor 6 (CELF6), which we also found to be associated with human autism. Specifically, these mice failed to potentiate exploratory hole\u2010poking behavior in response to familiarization to a rewarding stimuli. Characterization of <jats:italic>Celf6<\/jats:italic> gene expression showed high levels in monoaminergic populations such as the dopaminergic midbrain populations. To better understand the underlying behavioral disruption mediating the resistance to change exploratory behavior in the holeboard task, we tested three hypotheses: Does <jats:italic>Celf6<\/jats:italic> loss lead to global restricted patterns of behavior, failure of immediate response to reward or failure to alter behavior in response to reward (conditioning). We found the acute response to reward was intact, yet <jats:italic>Celf6<\/jats:italic> mutant mice exhibited impaired conditioned learning to both reward and aversive stimuli. Thus, we found that the resistance to change by the <jats:italic>Celf6<\/jats:italic> mutant in the holeboard was most parsimoniously explained as a failure of conditioning, as the mice had blunted responses even to potent rewarding stimuli such as cocaine. These findings further support the role of RBPs in conditioned learning.<\/jats:p>","DOI":"10.1111\/gbb.12593","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T10:44:50Z","timestamp":1560941090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-4722","authenticated-orcid":false,"given":"Susan E.","family":"Maloney","sequence":"first","affiliation":[{"name":"Department of Genetics Washington University School of Medicine  St. Louis Missouri"},{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri"},{"name":"Intellectual and Developmental Disabilities Research Center Washington University School of Medicine  St. Louis 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