{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:47:31Z","timestamp":1790718451987,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801126"],"award-info":[{"award-number":["81801126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670943"],"award-info":[{"award-number":["81670943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cellular polarity is crucial for brain development and morphogenesis. Lethal giant larvae 1 (Lgl1) plays a crucial role in the establishment of cell polarity from <jats:italic>Drosophila<\/jats:italic> to mammalian cells. Previous studies have found the importance of Lgl1 in the development of cerebellar, olfactory bulb, and cerebral cortex. However, the role of Lgl1 in hippocampal development during the embryonic stage and function in adult mice is still unknown. In our study, we created Lgl1\u2010deficient hippocampus mice by using Emx1\u2010Cre mice. Histological analysis showed that the Emx1\u2010Lgl1<jats:sup>\u2212\/\u2212<\/jats:sup> mice exhibited reduced size of the hippocampus with severe malformations of hippocampal cytoarchitecture. These defects mainly originated from the disrupted hippocampal neuroepithelium, including increased cell proliferation, abnormal interkinetic nuclear migration, reduced differentiation, increased apoptosis, gradual disruption of adherens junctions, and abnormal neuronal migration. The radial glial scaffold was disorganized in the Lgl1\u2010deficient hippocampus. Thus, Lgl1 plays a distinct role in hippocampal neurogenesis. In addition, the Emx1\u2010Lgl1<jats:sup>\u2212\/\u2212<\/jats:sup> mice displayed impaired behavioral performance in the Morris water maze and fear conditioning test.<\/jats:p>","DOI":"10.1111\/gbb.12605","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T12:39:55Z","timestamp":1565872795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lgl1 deficiency disrupts hippocampal development and impairs cognitive performance in mice"],"prefix":"10.1111","volume":"18","author":[{"given":"Tingting","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congzhe","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Reproductive medicine Second Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuoyang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Shandong Polytechnic  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-7107","authenticated-orcid":false,"given":"Jiangang","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91601-C"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(96)01002-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-05797.2002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-19120"},{"key":"e_1_2_7_6_1","first-page":"389","article-title":"MR evaluation of the hippocampus in patients with congenital malformations of the brain","volume":"22","author":"Sato N","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.356"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00225-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-004-1224-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5476.113"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.01.012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.5.1361"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1242\/jcs.109.6.1359","article-title":"A serine\u2010kinase associated with the p127\u2010l(2)gl tumour suppressor of Drosophila may regulate the binding of p127 to nonmuscle myosin II heavy chain and the attachment of p127 to the plasma membrane","volume":"109","author":"Kalmes A","year":"1996","journal-title":"J Cell Sci"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.127357"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/35046087"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.08.025"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.29387"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb948"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00244-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209508"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1164"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i26.4127"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2580"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"16703","DOI":"10.18632\/oncotarget.7697","article-title":"MiR\u2010652\u20103p is upregulated in non\u2010small cell lung cancer and promotes proliferation and metastasis by directly targeting Lgl1","volume":"7","author":"Yang W","year":"2016","journal-title":"Oncotarget"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1178004"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.07.007"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"e0182505","DOI":"10.1371\/journal.pone.0182505","article-title":"Correction: Lgl1 is required for olfaction and development of olfactory bulb in mice","volume":"12","author":"Li Z","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.12.039"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06309.2002"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.02.040"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074192"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5048-11.2012"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22204"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7427(03)00008-X"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2006.12.004"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.04.026"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.05.001"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.01.015"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1739"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22684"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.027"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9633-0"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03651"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.04.012"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90662-X"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2004.07.011"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.6.634"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20441"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/320447a0"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81279-9"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.08.029"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.2.274"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.02.014"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.754580"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu121"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.021"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2292"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-01-0015"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2254-13.2014"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202035899"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01645"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02938"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.078097"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-01-0073"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1924"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2072"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.4161\/cib.4.3.14886"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.05.002"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/35054077"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069871"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00255-7"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1744"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02330"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.013847"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-10-1462"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2870"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.03.036"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.118.1.53"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.897"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5772-09.2010"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/gbb.12605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T16:51:03Z","timestamp":1694191863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":79,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/gbb.12605"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12605","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"assertion":[{"value":"2018-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12605"}}