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Potential mechanisms include increased<jats:italic>Bdnf<\/jats:italic>expression, noradrenergic activity and modification of glutamate receptors. Because mice are commonly used to study exercise and brain plasticity, it is important to explore how acute exercise impacts behavior in this model. C57BL\/6J mice were assigned to three groups: control, moderate\u2010intensity running, and high\u2010intensity running. Control mice were placed on a stationary treadmill for 30\u2009minutes and moderate\u2010 and high\u2010intensity mice ran for 30\u2009minutes at 12 and 15\u201017\u2009m\/min, respectively. Mice were sacrificed immediately after running and the hippocampus removed. Total<jats:italic>Bdnf<\/jats:italic>,<jats:italic>Bdnf<\/jats:italic>exon IV, and glutamate receptor subunits were quantified with quantitative polymerase chain reaction. Total and phosphorylated GluR1 (Ser845 and Ser831) protein was quantified following immunoblotting. Utilizing the same protocol for control and high\u2010intensity running, object location memory was examined in a separate cohort of mice. Anxiety\u2010like behavior was assessed in the open field task (OFT) in a third cohort of mice that were separated into four groups: control\u2010saline, control\u2010DSP\u20104, acute exercise\u2010saline, and acute exercise\u2010DSP\u20104. DSP\u20104 was used to lesion the central noradrenergic system. We observed higher<jats:italic>Bdnf IV<\/jats:italic>mRNA in high\u2010intensity runners compared to controls, but no effects of acute exercise on memory. In the OFT, runners traveled less distance and spent more time grooming than controls. DSP\u20104 did not attenuate the effects of exercise. A single bout of exercise increases<jats:italic>Bdnf IV<\/jats:italic>mRNA in an intensity\u2010dependent manner; however, high\u2010intensity running reduces exploratory behavior in C57BL\/6J mice.<\/jats:p>","DOI":"10.1111\/gbb.12617","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T03:59:02Z","timestamp":1571284742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Acute forced exercise increases<i>Bdnf IV mRNA<\/i>and reduces exploratory behavior in C57BL\/6J mice"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-5379","authenticated-orcid":false,"given":"Andrew C.","family":"Venezia","sequence":"first","affiliation":[{"name":"Department of Exercise Science and Sport The University of Scranton Scranton Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly 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