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Previous work identified the trace amine\u2010associated receptor 1 gene (<jats:italic>Taar1<\/jats:italic>) as a quantitative trait gene for MA intake that also impacts thermal response to MA. All MAHDR mice are homozygous for the mutant <jats:italic>Taar1<\/jats:italic><jats:sup>\n<jats:italic>m1J<\/jats:italic><\/jats:sup> allele, whereas all MALDR mice possess at least one copy of the reference <jats:italic>Taar1<\/jats:italic><jats:sup>\n<jats:italic>+<\/jats:italic><\/jats:sup> allele. To determine if their differential sensitivity to MA\u2010induced hypothermia extends to drugs of similar and different classes, we examined sensitivity to the hypothermic effect of the stimulant cocaine, the amphetamine\u2010like substance 3,4\u2010methylenedioxymethamphetamine (MDMA), and the opioid morphine in these lines. The lines did not differ in thermal response to cocaine, only MALDR mice exhibited a hypothermic response to MDMA, and MAHDR mice were more sensitive to the hypothermic effect of morphine than MALDR mice. We speculated that the \u03bc\u2010opioid receptor gene (<jats:italic>Oprm1<\/jats:italic>) impacts morphine response, and genotyped the mice tested for morphine\u2010induced hypothermia. We report genetic linkage between <jats:italic>Taar1<\/jats:italic> and <jats:italic>Oprm1<\/jats:italic>; MAHDR mice more often inherit the <jats:italic>Oprm1<\/jats:italic><jats:sup>\n<jats:italic>D2<\/jats:italic><\/jats:sup> allele and MALDR mice more often inherit the <jats:italic>Oprm1<\/jats:italic><jats:sup>\n<jats:italic>B6<\/jats:italic><\/jats:sup> allele. Data from a family of recombinant inbred mouse strains support the influence of <jats:italic>Oprm1<\/jats:italic> genotype, but not <jats:italic>Taar1<\/jats:italic> genotype, on thermal response to morphine. These results nominate <jats:italic>Oprm1<\/jats:italic> as a genetic risk factor for morphine\u2010induced hypothermia, and provide additional evidence for a connection between drug preference and drug thermal response.<\/jats:p>","DOI":"10.1111\/gbb.12640","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T05:28:55Z","timestamp":1578720535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature\u2010altering effects of other addictive drugs"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-4340","authenticated-orcid":false,"given":"John R. 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