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These children often have comorbid neurodevelopmental\/psychiatric disorders, such as attention deficit\/hyperactivity disorder (ADHD). The genetics of RD and their overlap with other disorders is incompletely understood. To contribute to this, we performed a genome\u2010wide association study (GWAS) for word reading. Then, using summary statistics from neurodevelopmental\/psychiatric disorders, we computed polygenic risk scores (PRS) and used them to predict reading ability in our samples. This enabled us to test the shared aetiology between RD and other disorders. The GWAS consisted of 5.3 million single nucleotide polymorphisms (SNPs) and two samples; a family\u2010based sample recruited for reading difficulties in Toronto (n = 624) and a population\u2010based sample recruited in Philadelphia [Philadelphia Neurodevelopmental Cohort (PNC)] (n = 4430). The Toronto sample SNP\u2010based analysis identified suggestive SNPs (<jats:italic>P<\/jats:italic> ~\u20095 \u00d7\u200910<jats:sup>\u22127<\/jats:sup>) in the <jats:italic>ARHGAP23<\/jats:italic> gene, which is implicated in neuronal migration\/axon pathfinding. The PNC gene\u2010based analysis identified significant associations (<jats:italic>P<\/jats:italic> &lt;\u20092.72\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>) for <jats:italic>LINC00935<\/jats:italic> and <jats:italic>CCNT1<\/jats:italic>, located in the region of the <jats:italic>KANSL2\/CCNT1\/LINC00935\/SNORA2B\/SNORA34\/MIR4701\/ADCY6<\/jats:italic> genes on chromosome 12q, with near significant SNP\u2010based analysis. PRS identified significant overlap between word reading and intelligence (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.18, <jats:italic>P<\/jats:italic>\u2009=\u20097.25\u2009\u2009\u00d7\u200910<jats:sup>\u2212181<\/jats:sup>), word reading and educational attainment (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.07, <jats:italic>P<\/jats:italic>\u2009=\u20094.91\u2009\u00d7\u200910<jats:sup>\u221248<\/jats:sup>) and word reading and ADHD (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.02, <jats:italic>P<\/jats:italic>\u2009=\u20098.70\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>; threshold for significance = 7.14 \u00d7\u200910<jats:sup>\u22123<\/jats:sup>). Overlap was also found between RD and autism spectrum disorder (ASD) as top\u2010ranked genes were previously implicated in autism by rare and copy number variant analyses. These findings support shared risk between word reading, cognitive measures, educational outcomes and neurodevelopmental disorders, including ASD.<\/jats:p>","DOI":"10.1111\/gbb.12648","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T02:41:11Z","timestamp":1582857671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Genome\u2010wide association study of word reading: Overlap with risk genes for neurodevelopmental disorders"],"prefix":"10.1111","volume":"19","author":[{"given":"Kaitlyn M.","family":"Price","sequence":"first","affiliation":[{"name":"Genetics and Development Division Krembil Research Institute, University Health Network  Toronto Ontario Canada"},{"name":"Program in Neuroscience and Mental Health Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Physiology University of Toronto  Toronto Ontario 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