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Human continuous performance tasks (CPT), measure vigilance and cognitive control simultaneously while these processes are traditionally measured separately in rodents. We recently established a touchscreen 5\u2010choice CPT (5C\u2010CPT) that measures vigilance and cognitive control simultaneously by incorporating both target and nontargets and showed it was sensitive to amphetamine\u2010induced improvement in humans and mice. Here, we examined the effects of moderate prenatal alcohol exposure (PAE) in male and female mice on performance of the 5\u2010choice serial reaction time task (5\u2010CSRTT), which contained only target trials, and the 5C\u2010CPT which incorporated both target and nontarget trials. In addition, we assessed gait and fine motor coordination in behavioral na\u00efve PAE and control animals. We found that on the 5\u2010CSRTT mice were able to respond to target presentations with similar hit rates regardless of sex or treatment. However, on the 5C\u2010CPT PAE mice made significantly more false alarm responses vs controls. Compared with control animals, PAE mice had a significantly lower sensitivity index, a measure of ability to discriminate appropriate responses to stimuli types. During 5C\u2010CPT, female mice, regardless of treatment, also had increased mean latency to respond when correct and omitted more target trials. Gait assessment showed no significant differences in PAE and SAC mice on any measure. These findings suggest that moderate exposure to alcohol during development can have long lasting effects on cognitive control unaffected by gross motor alterations.<\/jats:p>","DOI":"10.1111\/gbb.12652","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T07:18:39Z","timestamp":1583565519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Moderate prenatal alcohol exposure impairs cognitive control, but not attention, on a rodent touchscreen continuous performance task"],"prefix":"10.1111","volume":"20","author":[{"given":"Sarah L.","family":"Olguin","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of New Mexico School of Medicine  Albuquerque New Mexico USA"},{"name":"New Mexico Alcohol Research Center, UNM Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico School of Medicine  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared W.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine University of California San Diego  La Jolla California USA"},{"name":"Research Service, VA San Diego Healthcare System  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-3263","authenticated-orcid":false,"given":"Jonathan L.","family":"Brigman","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico School of Medicine  Albuquerque New Mexico USA"},{"name":"New Mexico Alcohol Research Center, UNM Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2017-0077"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9167-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2008.01990.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460150065025"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1606"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S7256"},{"key":"e_1_2_8_8_1","first-page":"159","article-title":"Estimating the prevalence of fetal alcohol syndrome. 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