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Previous studies have pointed to the involvement of genes that regulate synaptic structure and function in the pathogenesis of these disorders. One such gene, <jats:italic>GRM7<\/jats:italic>, encodes the metabotropic glutamate receptor 7 (mGlu<jats:sub>7<\/jats:sub>), a G protein\u2010coupled receptor that regulates presynaptic neurotransmitter release. Mutations and polymorphisms in <jats:italic>GRM7<\/jats:italic> have been associated with neurodevelopmental disorders in clinical populations; however, limited preclinical studies have evaluated mGlu<jats:sub>7<\/jats:sub> in the context of this specific disease class. Here, we show that the absence of mGlu<jats:sub>7<\/jats:sub> in mice is sufficient to alter phenotypes within the domains of social behavior, associative learning, motor function, epilepsy and sleep. Moreover, <jats:italic>Grm7<\/jats:italic> knockout mice exhibit an attenuated response to amphetamine. These findings provide rationale for further investigation of mGlu<jats:sub>7<\/jats:sub> as a potential therapeutic target for neurodevelopmental disorders such as idiopathic autism, attention deficit hyperactivity disorder and Rett syndrome.<\/jats:p>","DOI":"10.1111\/gbb.12654","type":"journal-article","created":{"date-parts":[[2020,4,5]],"date-time":"2020-04-05T04:40:08Z","timestamp":1586061608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Phenotypic profiling of <scp>mGlu<sub>7<\/sub><\/scp> knockout mice reveals new implications for neurodevelopmental disorders"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-9618","authenticated-orcid":false,"given":"Nicole M.","family":"Fisher","sequence":"first","affiliation":[{"name":"Department of Pharmacology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Center for Neuroscience Drug Discovery Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Gould","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Center for Neuroscience Drug Discovery Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco G.","family":"Gogliotti","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Center for Neuroscience Drug Discovery Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalise J.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Center for Neuroscience Drug Discovery Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Badivuku","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Center for Neuroscience Drug Discovery Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Chennareddy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Center for Neuroscience Drug Discovery Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi B.","family":"Buch","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Center for Neuroscience Drug Discovery Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annah M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Center for Neuroscience Drug Discovery Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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