{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:02:47Z","timestamp":1775196167058,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA037927"],"award-info":[{"award-number":["DA037927"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA039841"],"award-info":[{"award-number":["DA039841"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA042103"],"award-info":[{"award-number":["DA042103"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Animal models of drug use have investigated possible mechanisms governing human substance use traits for over 100 years. Most cross\u2010species research on drug use\/addiction examines behavioral overlap, but studies assessing neuromolecular (e.g. RNA) correspondence are lacking. Our study utilized transcriptome\u2010wide data from the hippocampus and ventral tegmental area (VTA)\/midbrain from a total of 35 human males with cocaine use disorder\/controls and 49 male C57BL\/6J cocaine\/saline administering\/exposed mice. We hypothesized differential expressed genes and systems of co\u2010expressed genes (gene networks) would show appreciable overlap across mouse cocaine self\u2010administration and human cocaine use disorder. We found modest, but significant relationships between differentially expressed genes associated with cocaine self\u2010administration (short access) and cocaine use disorder within reward circuitry. Differentially expressed genes underlying models of acute cocaine exposure (cocaine), context re\u2010exposure and cocaine + context re\u2010exposure were not consistently associated with human CUD across brain regions. Investigating systems of co\u2010expressed genes, we found several validated gene networks with weak to moderate conservation between cocaine\/saline self\u2010administering mice and disordered cocaine users\/controls. The most conserved hippocampal and VTA gene networks demonstrated substantial overlap (2029 common genes) and included both novel and previously implicated targets for cocaine use\/addiction. Lastly, we conducted (expression\u2010based) phenome\u2010wide association studies of the nine\n                    <jats:italic>common<\/jats:italic>\n                    hub genes across conserved gene networks. Common hub genes were associated with dopamine\/serotonin function, cocaine self\u2010administration and other relevant mouse traits. Overall, our study pinpointed and characterized conserved brain\u2010related RNA patterns across mouse cocaine self\u2010administration and human cocaine use disorder. We offer recommendations for future research and add to the dialogue surrounding pre\u2010clinical animal research for human disease.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12689","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T01:06:21Z","timestamp":1595898381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Do gene expression findings from mouse models of cocaine use recapitulate human cocaine use disorder in reward circuitry?"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-7011","authenticated-orcid":false,"given":"Spencer B.","family":"Huggett","sequence":"first","affiliation":[{"name":"Behavioral Genetics of Addiction Laboratory Department of Psychology at Emory University Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Bubier","sequence":"additional","affiliation":[{"name":"Center for Systems Neurogenetics of Addiction The Jackson Laboratory Bar Harbor Maine USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissa J.","family":"Chesler","sequence":"additional","affiliation":[{"name":"Center for Systems Neurogenetics of Addiction The Jackson Laboratory Bar Harbor Maine USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan H. 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