{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:24:48Z","timestamp":1791901488098,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007030","name":"Les Turner ALS Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS05225"],"award-info":[{"award-number":["NS05225"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS087077"],"award-info":[{"award-number":["NS087077"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    For most metazoans, oxygen deprivation leads to cell dysfunction and if severe, death. Sublethal stress prior to a hypoxic or anoxic insult (\u201cpreconditioning\u201d) can protect cells from subsequent oxygen deprivation. The molecular mechanisms by which sublethal stress can buffer against a subsequent toxic insult and the role of the nervous system in the response are not well understood. We studied the role of neuronal activity preconditioning to oxygen deprivation in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    . Animals expressing the histamine gated chloride channels (HisCl1) in select cell populations were used to temporally and spatially inactivate the nervous system or tissue prior to an anoxic insult. We find that inactivation of the nervous system for 3\u2009h prior to the insult confers resistance to a 48\u2010h anoxic insult in 4th\u2010stage larval animals. Experiments show that this resistance can be attributed to loss of activity in cholinergic and GABAergic neurons as well as in body wall muscles. These observations indicate that the nervous system activity can mediate the organism's response to anoxia.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12713","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T23:00:13Z","timestamp":1604617213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preconditioning of\n                    <scp>\n                      <i>Caenorhabditis elegans<\/i>\n                    <\/scp>\n                    to anoxic insult by inactivation of cholinergic,\n                    <scp>GABAergic<\/scp>\n                    and muscle activity"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6250-4648","authenticated-orcid":false,"given":"Heather L.","family":"Bennett","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neurology Research Institute, Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Biology, Reem\u2010Kayden Center for Science and Computation Bard College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"McClanahan","sequence":"additional","affiliation":[{"name":"Department of Bioengineering School of Engineering and Applied Science, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Neuroscience Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Fang\u2010Yen","sequence":"additional","affiliation":[{"name":"Department of Bioengineering School of Engineering and Applied Science, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department 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