{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:45:29Z","timestamp":1772160329221,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA221260"],"award-info":[{"award-number":["R01CA221260"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA039168"],"award-info":[{"award-number":["R01DA039168"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA038738"],"award-info":[{"award-number":["R21DA038738"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["U01DA050243"],"award-info":[{"award-number":["U01DA050243"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Binge eating is a heritable trait associated with eating disorders and refers to the rapid consumption of a large quantity of energy\u2010dense food that is, associated with loss of control and negative affect. Binge eating disorder is the most common eating disorder in the United States; however, the genetic basis is unknown. We previously identified robust mouse inbred strain differences between C57BL\/6J and DBA\/2J in binge\u2010like eating of sweetened palatable food in an intermittent access, conditioned place preference paradigm. To map the genetic basis of changes in body weight and binge\u2010like eating (BLE) and to identify candidate genes, we conducted quantitative trait locus (QTL) analysis in 128 C57BL\/6J x DBA\/2J\u2010F2 mice combined with PheQTL and trait covariance analysis in GeneNetwork2 using legacy BXD\u2010RI trait datasets. We identified a QTL on Chromosome 18 influencing changes in body weight across days in females (log of the odds [LOD]\u00a0=\u00a06.3; 1.5\u2010LOD: 3\u201312\u2009cM) that contains the candidate gene\n                    <jats:italic>Zeb1<\/jats:italic>\n                    . We also identified a sex\u2010combined QTL influencing initial palatable food intake on Chromosome 5 (LOD\u00a0=\u00a05.8; 1.5\u2010LOD: 21\u201328\u2009cM) that contains the candidate gene\n                    <jats:italic>Lcorl<\/jats:italic>\n                    and a second QTL influencing escalated palatable food intake on Chromosome 6 in males (LOD\u00a0=\u00a05.4; 1.5\u2010LOD: 50\u201359\u2009cM) that contains the candidate genes\n                    <jats:italic>Adipor2<\/jats:italic>\n                    and\n                    <jats:italic>Plxnd1<\/jats:italic>\n                    . Finally, we identified a suggestive QTL in females for slope of BLE on distal Chromosome 18 (LOD\u00a0=\u00a04.1;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.055; 1.5\u2010LOD: 23\u201335\u2009cM). Future studies will use BXD\u2010RI strains to fine map loci and support candidate gene nomination for gene editing.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12751","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T10:07:22Z","timestamp":1620814042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systems genetic analysis of binge\u2010like eating in a C57BL\/6J x DBA\/2J\u2010F2 cross"],"prefix":"10.1111","volume":"20","author":[{"given":"Emily J.","family":"Yao","sequence":"first","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K.","family":"Babbs","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia C.","family":"Kelliher","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly P.","family":"Luttik","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristyn N.","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Graduate Program for Neuroscience Boston University  Boston Massachusetts USA"},{"name":"Tranformative Training Program in Addiction Science (TTPAS) Boston University  Boston Massachusetts USA"},{"name":"Biomolecluar Pharmacology Training Program Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Imad","family":"Damaj","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-635X","authenticated-orcid":false,"given":"Megan K.","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Department of Genetics, Genomics, and Informatics The University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4505-5809","authenticated-orcid":false,"given":"Camron D.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Graduate Program for Neuroscience Boston University  Boston Massachusetts USA"},{"name":"Tranformative Training Program in Addiction Science (TTPAS) Boston University  Boston Massachusetts USA"},{"name":"Biomolecluar Pharmacology Training Program Boston University School of Medicine  Boston Massachusetts 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