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To investigate psychiatric endophenotypes associated with\n                    <jats:italic>DLG2<\/jats:italic>\n                    haploinsufficiency (and concomitant PSD\u201093 protein reduction) a novel clinically relevant\n                    <jats:italic>Dlg2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    rat was assessed for abnormalities in anxiety, sensorimotor gating, hedonic reactions, social behaviour, and locomotor response to the N\u2010Methyl\u2010D\u2010aspartic acid receptor antagonist phencyclidine.\n                    <jats:italic>Dlg<\/jats:italic>\n                    gene and protein expression were also investigated to assess model validity. Reductions in PSD\u201093 messenger RNA and protein were observed in the absence of compensation by other related genes or proteins. Behaviourally\n                    <jats:italic>Dlg2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    rats show a potentiated locomotor response to phencyclidine, as is typical of psychotic disorder models, in the absence of deficits in the other behavioural phenotypes assessed here. This shows that the behavioural effects of\n                    <jats:italic>Dlg2<\/jats:italic>\n                    haploinsufficiency may specifically relate to psychosis vulnerability but are subtle, and partially dissimilar to behavioural deficits previously reported in\n                    <jats:italic>Dlg2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mouse models demonstrating issues surrounding the comparison of models with different aetiology and species. Intact performance on many of the behavioural domains assessed here, such as anxiety and reward processing, will remove these as confounds when continuing investigation into this model using more complex cognitive tasks.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12797","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T03:19:49Z","timestamp":1643080789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder"],"prefix":"10.1111","volume":"21","author":[{"given":"Sophie","family":"Waldron","sequence":"first","affiliation":[{"name":"School of Psychology Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Pass","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute Cardiff University  Cardiff UK"},{"name":"Neurobiology Research Unit Okinawa Institute of Science and Technology  Onna\u2010son Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonas","family":"Griesius","sequence":"additional","affiliation":[{"name":"Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience University of Bristol, University Walk  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack R.","family":"Mellor","sequence":"additional","affiliation":[{"name":"Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience University of Bristol, University Walk  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma S. 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