{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:50:26Z","timestamp":1787014226904,"version":"build-2736575974"},"reference-count":87,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mutations affecting\n                    <jats:italic>DLG2<\/jats:italic>\n                    are emerging as a genetic risk factor associated with neurodevelopmental psychiatric disorders including schizophrenia, autism spectrum disorder, and bipolar disorder. Discs large homolog 2 (DLG2) is a member of the membrane\u2010associated guanylate kinase protein superfamily of scaffold proteins, a component of the post\u2010synaptic density in excitatory neurons and regulator of synaptic function and plasticity. It remains an important question whether and how haploinsuffiency of DLG2 contributes to impairments in basic behavioural and cognitive functions that may underlie symptomatic domains in patients that cross diagnostic boundaries. Using a heterozygous\n                    <jats:italic>Dlg2<\/jats:italic>\n                    mouse model we examined the impact of reduced\n                    <jats:italic>Dlg2<\/jats:italic>\n                    expression on functions commonly impaired in neurodevelopmental psychiatric disorders including motor co\u2010ordination and learning, pre\u2010pulse inhibition and habituation to novel stimuli. The heterozygous\n                    <jats:italic>Dlg2<\/jats:italic>\n                    mice exhibited behavioural impairments in long\u2010term motor learning and long\u2010term habituation to a novel context, but not motor co\u2010ordination, initial responses to a novel context, PPI of acoustic startle or anxiety. We additionally showed evidence for the reduced regulation of the synaptic plasticity\u2010associated protein cFos in the motor cortex during motor learning. The sensitivity of selective behavioural and cognitive functions, particularly those dependent on synaptic plasticity, to reduced expression of DLG2 give further credence for DLG2 playing a critical role in specific brain functions but also a mechanistic understanding of symptom expression shared across psychiatric disorders.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12799","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T23:53:33Z","timestamp":1643932413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene\n                    <scp>\n                      <i>DLG2<\/i>\n                    <\/scp>"],"prefix":"10.1111","volume":"21","author":[{"given":"Rachel","family":"Pass","sequence":"first","affiliation":[{"name":"Neuroscience and Mental Health Research Institute Cardiff University  Cardiff UK"},{"name":"Okinawa Institute of Science and Technology  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Haan","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Humby","sequence":"additional","affiliation":[{"name":"School of Psychology Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute Cardiff University  Cardiff UK"},{"name":"School of Psychology Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Hall","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute Cardiff University  Cardiff UK"},{"name":"Medical Research Council Centre for Neuropsychiatric Genetics and Genomics Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3355-9583","authenticated-orcid":false,"given":"Kerrie L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute Cardiff University  Cardiff UK"},{"name":"School of Biosciences Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/MP.2012.23"},{"key":"e_1_2_8_3_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"Arlington V","year":"2013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1469\u20107610.2008.02046.X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.138"},{"key":"e_1_2_8_6_1","volume-title":"The Spectrum of Neurodevelopmental Disabilities,Capute & Accardo's Neurodevelopmental Disabilities in Infancy and Childhood: Neurodevelopmental Diagnosis and Treatment","author":"Capute AP","year":"2008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.154"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAP8757"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAD6469"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3903"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100344\u20108"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm546"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100059\u20102"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12489"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13595"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12929"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000274107"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3922"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2010.06.026"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JFMA.2013.01.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004580"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10110"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNCEL.2018.00470"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.021"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.11.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.18"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.01.006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155174"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.162"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12975"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048\u2010014\u20100394\u20100"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27491"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.015"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32232"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001558"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm151"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040\u20102392\u20105\u201036"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3992"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3276"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.02.011"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229\u2010020\u201000324\u20107"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.163469"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006838"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010017\u20100452\u2010y"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820030038005"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.4.636"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002068"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2016.00202"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092372"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.09.025"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116661075"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00123"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.05.028"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SCHRES.2017.08.050"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102826.2008.01734.x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3733\/hilg.v06n11p315"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0817s24"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.012"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_8_60_1","unstructured":"FranklinKBJ PaxinosG.Paxinos and Franklin's The Mouse Brain in Stereotaxic Coordinates"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/S000180050315"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.06.053"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0307"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01184-2"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.95.3.861"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:32:3:205"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1101\/LM.039537.115"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.5040\/9781492596844"},{"key":"e_1_2_8_69_1","first-page":"155","volume-title":"Warm\u2010Up and Flexibility","author":"Hoffman J","year":"2002"},{"key":"e_1_2_8_70_1","volume-title":"Motor Learning and Development","author":"Haibach PR","year":"2011"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/BIES.950070606"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/322419a0"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1101\/LM.3.5.402"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/CERCOR\/BHX060"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2011.10.008"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2261"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.09.010"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2008.09.012"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUBIOREV.2006.03.006"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1912049116"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2014.04.035"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/JNC.13580"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.91"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2011_195"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21\u201009\u201003085.2001"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NLM.2020.107323"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407575200"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0019\u201012.2013"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/gbb.12799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T09:30:43Z","timestamp":1692955843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,3]]},"references-count":87,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/gbb.12799"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12799","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.10.05.463181","asserted-by":"object"}]},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,3]]},"assertion":[{"value":"2021-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12799"}}