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GPM6B is thought to play a role in neuronal differentiation, myelination, and inactivation of the serotonin transporter via internalization. Recent human genome\u2010wide association studies (GWAS) have implicated membrane glycoproteins (both <jats:italic>GPM6B<\/jats:italic> and <jats:italic>GPM6A<\/jats:italic>) in the regulation of traits relevant to psychiatric disorders, including neuroticism, depressed affect, and delay discounting. Mouse studies have implicated <jats:italic>Gpm6b<\/jats:italic> in sensorimotor gating and regulation of serotonergic signaling. We used CRISPR to create a mutant Glycoprotein M6B (<jats:italic>Gpm6b<\/jats:italic>) allele on a C57BL\/6J mouse background. Because <jats:italic>Gpm6b<\/jats:italic> is located on the X chromosome, we focused on male <jats:italic>Gpm6b<\/jats:italic> mutant mice and their wild\u2010type littermates (WT) in two behavioral tests that measured aspects of impulsive or flexible decision\u2010making. We found that <jats:italic>Gpm6b<\/jats:italic> deletion caused deficits in a delay discounting task. In contrast, reward sensitivity was enhanced thereby facilitating behavioral flexibility and improving performance in the probabilistic reversal learning task. Taken together these data further delineate the role of <jats:italic>Gpm6b<\/jats:italic> in decision making behaviors that are relevant to multiple psychiatric disorders.<\/jats:p>","DOI":"10.1111\/gbb.12800","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T05:29:17Z","timestamp":1646371757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A mutant allele of glycoprotein M6\u2010B (<i>Gpm6b<\/i>) facilitates behavioral flexibility but increases delay discounting"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-5699","authenticated-orcid":false,"given":"Sandra","family":"Sanchez\u2010Roige","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"},{"name":"Department of Medicine, Division of Genetic Medicine Vanderbilt University Medical Center  Nashville 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