{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:45:30Z","timestamp":1772160330835,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61807023"],"award-info":[{"award-number":["61807023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2018JQ8015;2021JQ\u2010309"],"award-info":[{"award-number":["2018JQ8015;2021JQ\u2010309"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Reading disability exhibited defects in different cognitive domains, including word reading fluency, word reading accuracy, phonological awareness, rapid automatized naming and morphological awareness. To identify the genetic basis of Chinese reading disability, we conducted a genome\u2010wide association study (GWAS) of the cognitive traits related to Chinese reading disability in 2284\u00a0unrelated Chinese children. Among the traits analyzed in the present GWAS, we detected one genome\u2010wide significant association (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20095\u2009\u00d7\u200910\n                    <jats:sup>\u22128<\/jats:sup>\n                    ) on word reading fluency for one SNP on 4p16.2, within EVC genes (rs6446395,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a07.33\u2009\u00d7\u200910\n                    <jats:sup>\u221210<\/jats:sup>\n                    ). Rs6446395 also showed significant association with Chinese character reading accuracy (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a02.95\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    ), phonological awareness (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a07.11\u2009\u00d7\u200910\n                    <jats:sup>\u22123<\/jats:sup>\n                    ) and rapid automatized naming (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a04.71\u2009\u00d7\u200910\n                    <jats:sup>\u22123<\/jats:sup>\n                    ), implying multiple effects of this variant. The eQTL data showed that rs6446395 affected EVC expression in the cerebellum. Gene\u2010based analyses identified a gene (PRDM10) to be associated with word reading fluency at the genome\u2010wide level. Our study discovered a new candidate susceptibility variant for reading ability and provided new insights into the genetics of\u00a0developmental dyslexia in Chinese children.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12833","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:03:11Z","timestamp":1670983391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A genome\u2010wide association study identifies a new variant associated with word reading fluency in Chinese children"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-4167","authenticated-orcid":false,"given":"Zhengjun","family":"Wang","sequence":"first","affiliation":[{"name":"School of Psychology Shaanxi Normal University and Shaanxi Provincial Key Research Center of Child Mental and Behavioral Health  Xi'an 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Psychology Shaanxi Normal University and Shaanxi Provincial Key Research Center of Child Mental and Behavioral Health  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Psychology Shaanxi Normal University and Shaanxi Provincial Key Research Center of Child Mental and Behavioral Health  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Psychology Shaanxi Normal University and Shaanxi Provincial Key Research Center of Child Mental and Behavioral Health  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Shu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Psychology Shaanxi Normal University and Shaanxi Provincial Key Research Center of Child Mental and Behavioral Health  Xi'an China"},{"name":"The School of Life Sciences Central South University  Changsha China"},{"name":"Department of Psychiatry SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-6227","authenticated-orcid":false,"given":"Jingjing","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Psychology Shaanxi Normal University and Shaanxi Provincial Key Research Center of Child Mental and Behavioral Health  Xi'an 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