{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:34:21Z","timestamp":1784302461516,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P50DA039841"],"award-info":[{"award-number":["P50DA039841"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["U01DA043809"],"award-info":[{"award-number":["U01DA043809"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The gut\u2010brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion of the microbiome by antibiotic treatment alters cocaine\u2010induced behavioral sensitization in C57BL\/6J male mice. Some reports suggest that cocaine\u2010induced behavioral sensitization is correlated with drug self\u2010administration behavior in mice. Here, we profile the composition of the na\u00efve microbiome and its response to cocaine sensitization in two collaborative cross (CC) strains. These strains display extremely divergent behavioral responses to cocaine sensitization. A high\u2010responding strain, CC004\/TauUncJ (CC04), has a gut microbiome that contains a greater amount of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    than the cocaine\u2010nonresponsive strain CC041\/TauUncJ (CC41). The gut microbiome of CC41 is characterized by an abundance of\n                    <jats:italic>Eisenbergella<\/jats:italic>\n                    ,\n                    <jats:italic>Robinsonella<\/jats:italic>\n                    and\n                    <jats:italic>Ruminococcus.<\/jats:italic>\n                    In response to cocaine, CC04 has an increased\n                    <jats:italic>Barnsiella<\/jats:italic>\n                    population, while the gut microbiome of CC41 displays no significant changes. PICRUSt functional analysis of the functional potential of the gut microbiome in CC04 shows a significant number of potential gut\u2010brain modules altered after exposure to cocaine, specifically those encoding for tryptophan synthesis, glutamine metabolism, and menaquinone synthesis (vitamin K2). Depletion of the microbiome by antibiotic treatment revealed an altered cocaine\u2010sensitization response following antibiotics in female CC04 mice. Depleting the microbiome by antibiotic treatment in males revealed increased infusions for CC04 during a cocaine intravenous self\u2010administration dose\u2013response curve. Together these data suggest that genetic differences in cocaine\u2010related behaviors may involve the microbiome.\n                  <\/jats:p>","DOI":"10.1111\/gbb.12845","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T02:47:26Z","timestamp":1682650046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice"],"prefix":"10.1111","volume":"22","author":[{"given":"Thi Dong Binh","family":"Tran","sequence":"first","affiliation":[{"name":"The Jackson Laboratory for Genomic Medicine  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Monroy Hernandez","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory for Mammalian Genetics  Bar Harbor Maine 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