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Recent studies have reported disrupted brain circuit function and behaviour in models of Dlg2 knockout and haploinsufficiency. Specifically, deficits in hippocampal synaptic plasticity were found in heterozygous Dlg2+\/\u2212 rats suggesting impacts on hippocampal dependent learning and cognitive flexibility. Here, we tested these predicted effects with a behavioural characterisation of the heterozygous Dlg2+\/\u2212 rat model. Dlg2+\/\u2212 rats exhibited a specific, mild impairment in reversal learning in a substrate deterministic bowl\u2010digging reversal learning task. The performance of Dlg2+\/\u2212 rats in other bowl digging task, visual discrimination and reversal, novel object preference, novel location preference, spontaneous alternation, modified progressive ratio, and novelty\u2010suppressed feeding test were not impaired. These findings suggest that despite altered brain circuit function, behaviour across different domains is relatively intact in Dlg2+\/\u2212 rats, with the deficits being specific to only one test of cognitive flexibility. The specific behavioural phenotype seen in this Dlg2+\/\u2212 model may capture features of the clinical presentation associated with variation in the Dlg2 gene.<\/jats:p>","DOI":"10.1111\/gbb.12865","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:40:19Z","timestamp":1694666419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A mild impairment in reversal learning in a bowl\u2010digging substrate deterministic task but not other cognitive tests in the Dlg2+\/\u2212 rat model of genetic risk for psychiatric disorder"],"prefix":"10.1111","volume":"22","author":[{"given":"Simonas","family":"Griesius","sequence":"first","affiliation":[{"name":"Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Waldron","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute, Psychology  Cardiff UK"},{"name":"Department of Psychology  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie A.","family":"Kamenish","sequence":"additional","affiliation":[{"name":"Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Cherbanich","sequence":"additional","affiliation":[{"name":"Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute, Psychology  Cardiff UK"},{"name":"Department of Psychology  Cardiff UK"},{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics, Schools of Medicine and Genetics and Genomics, Schools of Medicine and Psychology  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3355-9583","authenticated-orcid":false,"given":"Kerrie L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute, Psychology  Cardiff UK"},{"name":"Department of Medicine and Psychology  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Hall","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute, Psychology  Cardiff UK"},{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics, Schools of Medicine and Genetics and Genomics, Schools of Medicine and Psychology  Cardiff UK"},{"name":"Department of Medicine and Psychology  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack R.","family":"Mellor","sequence":"additional","affiliation":[{"name":"Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-5508","authenticated-orcid":false,"given":"Dominic M.","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute, Psychology  Cardiff UK"},{"name":"Department of Psychology  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-6541","authenticated-orcid":false,"given":"Emma S. 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